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B Cell Receptor Signaling

  • Tomohiro Kurosaki
  • Jürgen Wienands

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 393)

Table of contents

  1. Front Matter
    Pages i-x
  2. Rudolf Übelhart, Markus Werner, Hassan Jumaa
    Pages 3-25
  3. Jianying Yang, Michael Reth
    Pages 27-43
  4. Robbert Hoogeboom, Pavel Tolar
    Pages 45-63
  5. Odilia B. J. Corneth, Roel G. J. Klein Wolterink, Rudi W. Hendriks
    Pages 67-105
  6. Jürgen Wienands, Niklas Engels
    Pages 107-121
  7. Klaus Okkenhaug, Jan A. Burger
    Pages 123-142 Open Access
  8. Yoshihiro Baba, Tomohiro Kurosaki
    Pages 143-174
  9. Yoshiteru Sasaki, Kazuhiro Iwai
    Pages 177-209

About this book

Introduction

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

Keywords

B cell development Calcium signaling MAP kinase PI3K signaling Autoimmunity Lymphoma B cell antigen receptor BCR signaling BTK Bruton’s tyrosine kinase MAP kinase cascades Antigen receptor signaling B cell activation B cell differentiation

Editors and affiliations

  • Tomohiro Kurosaki
    • 1
  • Jürgen Wienands
    • 2
  1. 1.WPI Immunology Frontier Research CenterOsaka UniversityOsakaJapan
  2. 2.Cellular and Molecular ImmunologyGeorg August University GoettingenGöttingen Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-26133-1
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-26131-7
  • Online ISBN 978-3-319-26133-1
  • Series Print ISSN 0070-217X
  • Series Online ISSN 2196-9965
  • Buy this book on publisher's site