OCT in Central Nervous System Diseases

The Eye as a Window to the Brain

  • Andrzej Grzybowski
  • Piero Barboni

Table of contents

  1. Front Matter
    Pages i-vi
  2. Andrzej Grzybowski, Piero Barboni
    Pages 1-5
  3. Tigran Kostanyan, Gadi Wollstein, Joel S. Schuman
    Pages 7-34
  4. Kendra A. Klein, Thomas R. Hedges III
    Pages 35-68
  5. Mário Luiz Ribeiro Monteiro
    Pages 69-86
  6. Rachel C. Nolan, Kannan Narayana, Laura J. Balcer, Steven L. Galetta
    Pages 87-104
  7. Shahnaz Miri, Sofya Glazman, Ivan Bodis-Wollner
    Pages 105-121
  8. Gianluca Coppola, Vincenzo Parisi, Gianluca Manni, Francesco Pierelli, Alfredo A. Sadun
    Pages 123-142
  9. Andrzej Grzybowski, Francisco J. Ascaso, Javier Mateo, Laura Cabezón, Paula Casas
    Pages 167-183
  10. Piero Barboni, Giacomo Savini, Alfredo A. Sadun
    Pages 185-203
  11. Bernardo F. Sanchez-Dalmau, Ruben Torres-Torres, Johannes Keller, Elena H. Martínez-Lapiscina, Pablo Villoslada
    Pages 205-214
  12. Carl Arndt, Sourabh Sharma, Dan Milea, Tony Garcia, Andrzej Grzybowski
    Pages 215-238
  13. Eduardo M. Normando, James T. Brodie, M. Francesca Cordeiro
    Pages 239-263
  14. Kaweh Mansouri, Robert N. Weinreb
    Pages 265-288
  15. Paolo Nucci, Andrea Lembo, Greta Castellucci, Francesco Pichi
    Pages 289-296
  16. Piero Barboni, Andrzej Grzybowski
    Pages 297-299
  17. Back Matter
    Pages 301-342

About this book


This book reviews recent important advances in the use of optical coherence tomography (OCT) in order to analyze neurodegeneration within the retina through the quantification of axonal loss. Detailed information is provided on the role of OCT as a promising tool for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. The disorders considered include multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models.

As well as being a valuable tool for diagnosis of many retinal diseases and monitoring of surgical and medical treatment, OCT allows study of the retinal nerve fiber layer (RNFL) containing the axons of the retinal ganglion cells, which form the optic nerves, chiasm, and optic tracts. Since retinal axons are nonmyelinated until they penetrate the lamina cribrosa, the RNFL is an ideal structure for visualization of any process of neurodegeneration, neuroprotection, or regeneration. It is for this reason that OCT has been applied in various areas of neurology over the past decade, becoming a hot topic and generating great enthusiasm among neurologists and ophthalmologists. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.


Neurodegenerative Diseases Optic Neuropathy Optical Coherence Topography RNFL Retinal Nerve Fiber Layer

Editors and affiliations

  • Andrzej Grzybowski
    • 1
  • Piero Barboni
    • 2
  1. 1.Head of Ophthalmology DepartmentProfessor of Ophthalmology,PoznańPoland
  2. 2.Studio Oculistico d’AzeglioBolognaItaly

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-24083-1
  • Online ISBN 978-3-319-24085-5
  • Buy this book on publisher's site