Quasispecies: From Theory to Experimental Systems

  • Esteban Domingo
  • Peter Schuster

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 392)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Esteban Domingo, Peter Schuster
    Pages 1-22
  3. Peter F. Stadler
    Pages 43-59
  4. Peter Schuster
    Pages 61-120
  5. Nathaniel Wagner, Yoav Atsmon-Raz, Gonen Ashkenasy
    Pages 141-159
  6. Héctor Tejero, Francisco Montero, Juan Carlos Nuño
    Pages 161-179
  7. Yuta Shirogane, Shumpei Watanabe, Yusuke Yanagi
    Pages 219-229
  8. Ana Grande-Pérez, Veronica Martin, Hector Moreno, Juan C. de la Torre
    Pages 231-275
  9. Pranesh Padmanabhan, Narendra M. Dixit
    Pages 277-302
  10. Antonio V. Bordería, Kathryn Rozen-Gagnon, Marco Vignuzzi
    Pages 303-322
  11. Celia Perales, Esteban Domingo
    Pages 323-339
  12. Back Matter
    Pages 341-357

About this book


This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology. 


RNA interactions Antiviral strategies Lethal mutagenesis Viral population dynamics Virus spread Viral disease events Viral disease control Drug-resistant mutants Antiviral treatments

Editors and affiliations

  • Esteban Domingo
    • 1
  • Peter Schuster
    • 2
  1. 1.Campus de CantoblancoCentro de Biología Molecular Severo Ochoa (CSIC-UAM)MadridSpain
  2. 2.The Santa Fe Institute, Santa Fe, NM, USA and Institut f. Theoretische ChemieUniversität WienViennaAustria

Bibliographic information