Advertisement

© 2016

Organic Cation Transporters

Integration of Physiology, Pathology, and Pharmacology

  • Giuliano Ciarimboli
  • Sophie Gautron
  • Eberhard Schlatter
Book

Table of contents

About this book

Introduction

This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues.

 

This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.

Keywords

Cell Membrane Cytoplasm Genetics Molecular biology Structural biology

Editors and affiliations

  • Giuliano Ciarimboli
    • 1
  • Sophie Gautron
    • 2
  • Eberhard Schlatter
    • 3
  1. 1.Experimental Nephrology, MC DUniversity of MünsteMünsterGermany
  2. 2.CNRS UMR8246/Inserm U1130/UPMC UMCR18/Sorbonne UniversityNeuroscience Institute of Biology Paris-SeineParisFrance
  3. 3.Experimental Nephrology, MC DUniversity Hospital MünsteMünsterGermany

Bibliographic information

Reviews

“This encyclopedic resource provides extensively detailed, state-of-the-art information about cellular organic cation transporters and their relevance to human function and disease. … This is a magnificent resource for scientists actively engaged in any research related to the biology of organic ion transporters. Every conceivable topic related to these transporters is addressed, making it useful for active researchers in a wide variety of biomedical and biological disciplines.” (David R. Bell, Doody’s Book Reviews, April, 2016)