Table of contents
About this book
The advances of live cell video imaging and high-throughput technologies for functional and chemical genomics provide unprecedented opportunities to understand how biological processes work in subcellular and multicellular systems. The interdisciplinary research field of Video Bioinformatics is defined by Bir Bhanu as the automated processing, analysis, understanding, data mining, visualization, query-based retrieval/storage of biological spatiotemporal events/data and knowledge extracted from dynamic images and microscopic videos. Video bioinformatics attempts to provide a deeper understanding of continuous and dynamic life processes.
Genome sequences alone lack spatial and temporal information, and video imaging of specific molecules and their spatiotemporal interactions, using a range of imaging methods, are essential to understand how genomes create cells, how cells constitute organisms, and how errant cells cause disease. The book examines interdisciplinary research issues and challenges with examples that deal with organismal dynamics, intercellular and tissue dynamics, intracellular dynamics, protein movement, cell signaling and software and databases for video bioinformatics.
Topics and Features
Covers a set of
biological problems, their significance, live-imaging experiments, theory and computational
methods, quantifiable experimental results and discussion of results.
methods for analyzing mild traumatic brain injury over time, identifying injury
dynamics after neonatal hypoxia-ischemia and visualizing cortical tissue
changes during seizure activity as examples of organismal dynamics
Describes techniques for
quantifying the dynamics of human embryonic stem cells with examples of cell
detection/segmentation, spreading and other dynamic behaviors which are
important for characterizing stem cell health
Examines and quantifies
dynamic processes in plant and fungal systems such as cell trafficking, growth
of pollen tubes in model systems such as Neurospora Crassa and Arabidopsis
Discusses the dynamics
of intracellular molecules for DNA repair and the regulation of cofilin transport
using video analysis
system and database aspects of video bioinformatics by providing examples of 5D
cell tracking by FARSIGHT open source toolkit, a survey on available databases
and software, biological processes for non-verbal communications and
identification and retrieval of moth images
This unique text will be of great interest to researchers and graduate students of Electrical Engineering, Computer Science, Bioengineering, Cell Biology, Toxicology, Genetics, Genomics, Bioinformatics, Computer Vision and Pattern Recognition, Medical Image Analysis, and Cell Molecular and Developmental Biology. The large number of example applications will also appeal to application scientists and engineers.
Dr. Bir Bhanu is Distinguished Professor of Electrical & Computer Engineering, Interim Chair of the Department of Bioengineering, Cooperative Professor of Computer Science & Engineering, and Mechanical Engineering and the Director of the Center for Research in Intelligent Systems, at the University of California, Riverside, California, USA.
Dr. Prue Talbot is Professor of Cell Biology & Neuroscience and Director of the Stem Cell Center and Core at the University of California Riverside, California, USA.
Editors and affiliations
- DOI https://doi.org/10.1007/978-3-319-23724-4
- Copyright Information Springer International Publishing Switzerland 2015
- Publisher Name Springer, Cham
- eBook Packages Computer Science Computer Science (R0)
- Print ISBN 978-3-319-23723-7
- Online ISBN 978-3-319-23724-4
- Series Print ISSN 1568-2684
- Buy this book on publisher's site