Prokaryotic Systems Biology

  • Nevan J. Krogan, PhD
  • Mohan Babu, PhD

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 883)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Ana Popovic, Anatoly Tchigvintsev, Hai Tran, Tatyana N. Chernikova, Olga V. Golyshina, Michail M. Yakimov et al.
    Pages 1-20
  3. Karine Dufresne, Catherine Paradis-Bleau
    Pages 41-76
  4. Cedoljub Bundalovic-Torma, John Parkinson
    Pages 77-96
  5. Viktor Deineko, Ashwani Kumar, James Vlasblom, Mohan Babu
    Pages 135-154
  6. Hirotada Mori, Rikiya Takeuchi, Yuta Otsuka, Steven Bowden, Katsushi Yokoyama, Ai Muto et al.
    Pages 155-168
  7. Omar Wagih, Leopold Parts
    Pages 169-185
  8. Charles Calmettes, Andrew Judd, Trevor F. Moraes
    Pages 255-270
  9. Colin A. Cooper, Iain L. Mainprize, Nicholas N. Nickerson
    Pages 295-315
  10. Back Matter
    Pages 317-319

About this book


This book focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species. The first part of the volume consists of nine chapters, focusing on biochemical and genetics and genomics approaches including yeast two hybrid, metagenomics, affinity purification in combination with mass spectrometry, chromatin-immunoprecipitation coupled with sequencing, large-scale synthetic genetic screens, and quantitative-based mass spectrometry strategies for mapping the bacterial physical, functional, substrate, and regulatory interaction networks needed for interpreting biological networks, inferring gene function, enzyme discovery, and identifying new drug targets.

The second part comprises five chapters, covering the network of participants for protein folding and complex enzyme maturation. It also covers the structural approaches required to understand bacterial intramembrane proteolysis and the structure and function of bacterial proteins involved in surface polysaccharides, outer membrane, and envelope assembly.

This volume concludes with a focus on computational and comparative genomics approaches, especially network-based methods for predicting physical or functional interactions, and integrative analytical approaches for generating more reliable information on bacterial gene function. This book provides foundational knowledge in the understanding of prokaryotic systems biology by illuminating how bacterial genes f

unction within the framework of global cellular processes. The book will enable the microbiology community to create substantive resources for addressing many pending unanswered questions, and facilitate the development of new technologies that can be applied to other bacterial species lacking experimental data. ​ ​


genomics integrative biology prokaryotes proteomics systems biology

Editors and affiliations

  • Nevan J. Krogan, PhD
    • 1
  • Mohan Babu, PhD
    • 2
  1. 1.Cellular and Molecular PharmacologyUniv of California, San FranciscoSAN FRANCISCOUSA
  2. 2.Department of BiochemistryUniversity of ReginaReginaCanada

Bibliographic information