Advances in Geroscience

  • Felipe Sierra
  • Ronald Kohanski

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Shenghui He, Norman E. Sharpless
    Pages 53-83
  3. Changhan Lee, Valter Longo
    Pages 85-119
  4. Ying Ann Chiao, Edward Lakatta, Zoltan Ungvari, Dao-Fu Dai, Peter Rabinovitch
    Pages 121-160
  5. Farida Sohrabji
    Pages 161-196
  6. Geoffrey A. Kerchner, Tony Wyss-Coray
    Pages 197-227
  7. Julie K. Andersen, Shankar Chinta
    Pages 229-255
  8. Simon Melov, Clifford J. Rosen
    Pages 257-275
  9. Julie Glowacki, Tamara Vokes
    Pages 277-307
  10. Richard F. Loeser, Martin Lotz
    Pages 309-353
  11. Nicolas Musi, Andrzej Bartke
    Pages 355-376
  12. John P. Higgins, Stuart K. Kim
    Pages 377-396
  13. Nicola A. Hanania, Paula Busse
    Pages 397-428
  14. Cecilia G. Sanchez
    Pages 429-470
  15. Charles Wright, Jayakrishna Ambati
    Pages 471-507
  16. Anna Hearps, Katherine Schafer, Kevin High, Alan Landay
    Pages 509-550
  17. Roger B. Fillingim, Dennis C. Turk, Robert P. Yezierski
    Pages 551-592
  18. James L. Kirkland, Tamar Tchkonia
    Pages 593-622

About this book


This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’


The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV.  It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.


Aging and Stroke Aging hypotheses Aging main risk factor most chronic diseases Cancer and Aging Cardiovascular disease Depression, Dementia and Aging Epidemiology New discipline geroscience Osteoporosis and Osteoarthritis Parkinson's Disease and Aging Vision impairmant

Editors and affiliations

  • Felipe Sierra
    • 1
  • Ronald Kohanski
    • 2
  1. 1.National Inst. of Aging Division of Aging BiologyNational Institutes of HealthBethesdaUSA
  2. 2.National Inst on Aging/ National Inst of HealthDivision of Aging BiologyBethesdaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-23245-4
  • Online ISBN 978-3-319-23246-1
  • Buy this book on publisher's site