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Synthetic and Biophysical Studies on the Tridachiahydropyrone Family of Natural Products

  • Kimberley Jade Powell

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Synthetic and Biophysical Studies on the Tridachiahydropyrone Family of Natural Products

    1. Front Matter
      Pages 1-1
    2. Kimberley Jade Powell
      Pages 3-24
    3. Kimberley Jade Powell
      Pages 73-75
    4. Kimberley Jade Powell
      Pages 77-101
  3. Synthesis of Alkenyl Nitriles by the Palladium-Catalysed Cyanation of Vinyl Halides with Acetone Cyanohydrin

  4. Back Matter
    Pages 131-136

About this book

Introduction

This thesis addresses fundamental scientific questions such as:
How are complex natural products synthesized in vivo?
Can we replicate these conditions in a laboratory environment?
What is the biological function of such secondary metabolites?
What are the biological origins of chirality?
These issues are explored in an accessible manner using a multidisciplinary approach spanning chemistry, biology and physics to investigate an interesting family of complex natural products isolated from marine molluscs – the tridachiahydropyrones.
 
The work has achieved:
Elegant biomimetic syntheses of a number of the tridachiahydropyrone compounds in vitro using organic synthesis techniques
The characterization of the interactions between these compounds and a range of model membrane systems using a series of fluorescence spectroscopic studies
The investigation of the antioxidant and photoprotective properties of the compounds by means of biophysical assay techniques
The synthesis of tridachiahydropyrone utilizing the model membrane systems as biomimetic reaction media.

Keywords

Asymmetric electrocyclisation Biomimetic electrocyclisation Biomimetic synthesis Cyanation of vinyl halides/cyanation of alkenyl halides Fluorescence spectroscopy Lipid peroxidation Marine natural products Membrane antioxidants Natural product synthesis Palladium catalysed cyanation

Authors and affiliations

  • Kimberley Jade Powell
    • 1
  1. 1.School of ChemistryUniversity of NottinghamNottinghamUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-22069-7
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-22068-0
  • Online ISBN 978-3-319-22069-7
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • Buy this book on publisher's site