Inflammatory Pathways in Diabetes

Biomarkers and Clinical Correlates

  • MichaelĀ Pugia

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Introduction

  3. Impact of Complement on Diabetic Disease

    1. Front Matter
      Pages 27-27
    2. Jose A. Halperin, Pamela Ghosh, Michael Chorev, Anand Vaidya
      Pages 29-57
  4. Role of C Terminal Fragment of Adiponectin Receptor in Inhibition of Insulin Degradation

  5. Uristatin Assay for Prediction of Renal and Other Clinical Events

    1. Front Matter
      Pages 125-125
    2. Saeed A. Jortani, Michael Pugia
      Pages 127-141
    3. Mitchell H. Rosner, Michael Pugia
      Pages 143-156
    4. Saeed A. Jortani, Michael Pugia
      Pages 157-170
    5. Manju Basu, Subhash Basu, Michael Pugia
      Pages 171-190
  6. Summary

    1. Front Matter
      Pages 191-191
  7. Back Matter
    Pages 215-219

About this book


This book discusses recent advances in new anti- and pro-inflammatory pathways in diabetic disease, and identifies new diagnostic immunological methods that offer potential companion diagnostics for diabetic diseases. New methods in proteomics, mass spectroscopy, immunological assay design, measurement of cellular signal transduction and protease inhibition are used to clarify new biochemical pathways. Biomarker validation in animal models and correlations in humans for diagnostic clinical trials shed new light on the impact of diabetic diseases. The book reviews current understanding of inflammatory pathways in the pathophysiology of insulin resistance, metabolic syndrome, nephritis and other diabetic inflammatory conditions, and is the first to describe the impact of novel adipokines, protease inhibitors and complement markers. By presenting new methodologies for biomarker discovery, it provides a valuable resource for researchers studying clinical diagnosis, drug development, bio-analytical chemistry, proteomics and biochemistry. It is also useful for those conducting clinical and biological studies for targeted drug development. The methodologies and approaches can be applied to other markers, and the information will be helpful in the preparation of research grant applications.


adiponectin receptor biomarkers diabetic diseases diagnostic methods inflammatory pathways

Editors and affiliations

  • MichaelĀ Pugia
    • 1
  1. 1.Strategic InnovationSiemens Healthcare DiagnosticsElkhartUSA

Bibliographic information