Developments in T Cell Based Cancer Immunotherapies

  • Paolo A. Ascierto
  • David F. Stroncek
  • Ena Wang

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Kwong Y. Tsang, Caroline Jochems, Jeffrey Schlom
    Pages 1-27
  3. Jay A. Berzofsky, Lauren V. Wood, Masaki Terabe
    Pages 29-52
  4. Joel Crespo, Ilona Kryczek, Theodore Welling, Shuang Wei, Weiping Zou
    Pages 53-74
  5. Kaoru Nagato, Timothy T. Spear, Michael I. Nishimura
    Pages 75-98
  6. Davide Bedognetti, Sara Tomei, Wouter Hendrickx, Francesco M. Marincola, Ena Wang
    Pages 99-127
  7. David Stroncek, Jianjian Jin, Virginia David-Ocampo, Vicki Fellowes, Larry Moses, Marianna Sabatino
    Pages 129-150
  8. Jessica Chacon, Krit Ritthipichai, Geok Sim, Michiko Harao, Jie Qing Chen, Caitlin Creasy et al.
    Pages 151-181
  9. Giuseppe V. Masucci, Luigi De Petris, Andreas Lundqvist, Rolf Kiessling, Rolf Lewensohn
    Pages 211-229
  10. Patrick A. Ott, F. Stephen Hodi
    Pages 231-244
  11. Maria Libera Ascierto, Salvador Martin Algarra, Ignacio Melero, Paolo A. Ascierto
    Pages 245-258
  12. Daniel W. Lee, Alan S. Wayne
    Pages 259-280
  13. Paolo A. Ascierto, David F. Stroncek, Ena Wang
    Pages E1-E1
  14. Back Matter
    Pages 303-305

About this book


This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.


Cell Therapy adoptive t cell therapy cancer immunology cancer immunotherapy t cell biology

Editors and affiliations

  • Paolo A. Ascierto
    • 1
  • David F. Stroncek
    • 2
  • Ena Wang
    • 3
  1. 1.Unit of Melanoma & Cancer ImmunotherapyNational Tumor Institute Fondazione G.NaplesItaly
  2. 2.Department of Transfusion MedicineNational Institutes of HealthBethesdaUSA
  3. 3.Department of Transfusion MedicineNational Institutes of HealthBETHESDAUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-21166-4
  • Online ISBN 978-3-319-21167-1
  • Series Print ISSN 2196-9906
  • Series Online ISSN 2196-9914
  • Buy this book on publisher's site