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Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer

  • Daniel L. Miller
  • M. Sharon Stack

Table of contents

  1. Front Matter
    Pages i-viii
  2. Lucia Pirisi, Swati Tomar, Saundra H. Glover
    Pages 43-68
  3. Eric A. Smith, Marie C. Matrka, Susanne I. Wells
    Pages 69-101
  4. Sara P. Culleton, Elliot J. Androphy, Sriramana Kanginakudru
    Pages 103-132
  5. Hua Li, Jennifer R. Grandis
    Pages 171-194
  6. Michael Moore, Marion Couch
    Pages 195-212
  7. Panagiota Economopoulou, Amanda Psyrri
    Pages 213-229
  8. Neil Gildener-Leapman, Seungwon Kim
    Pages 231-241
  9. Anna-Maria De Costa, Thorsten Rieckmann, Randall J. Kimple
    Pages 243-289
  10. Back Matter
    Pages 307-314

About this book

Introduction

Head and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health efforts encouraging smoking cessation, the overall incidence of HNSCC has decreased in recent years in many countries.  In contrast, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly, and this subtype of HNSCC is commonly associated with human papillomavirus (HPV) infection.  Moreover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity.

 

This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. Chapters are contributed by authoritative leaders in the fields of research and clinical care. Initial chapters address epidemiology, behavioral correlates of HPV infection, and racial disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with focus on viral transformation, viral replication, and host response to viral infection. The molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in signaling networks and unique mutational profiles of human tumors. Clinical presentation, surgical perspectives, and treatment paradigms specific to HPV-associated OPSCC conclude the volume.  This comprehensive volume provides an up-to-date overview of both scientific discovery and clinical management of this emerging public health problem.

Keywords

HPV Head and neck squamous cell carcinoma Human Papillomavirus Oropharynx Precision medicine oropharyngeal cancer

Editors and affiliations

  • Daniel L. Miller
    • 1
  • M. Sharon Stack
    • 2
  1. 1.School of MedicineUniversity of MissouriColumbiaUSA
  2. 2.Department of Chemistry and Biochemistry, Harper Cancer Research InstituteUniversity of Notre DameSouth BendUSA

Bibliographic information