The Adenosinergic System

A Non-Dopaminergic Target in Parkinson’s Disease

  • Micaela Morelli
  • Nicola Simola
  • Jadwiga Wardas

Part of the Current Topics in Neurotoxicity book series (Current Topics Neurotoxicity, volume 10)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Nicola Simola, Jadwiga Wardas
    Pages 1-25
  3. Sergi Ferré, Gemma Navarro, Jordi Bonaventura, Estefanía Moreno, Nora D. Volkow, Carme Lluís et al.
    Pages 27-38
  4. Maria J. Diógenes, Joaquim A. Ribeiro, Ana M. Sebastião
    Pages 57-79
  5. Catarina Gomes, Jimmy George, Jiang-Fan Chen, Rodrigo A. Cunha
    Pages 81-99
  6. Rachit Bakshi, Robert Logan, Michael A. Schwarzschild
    Pages 101-126
  7. John D. Salamone, Samantha J. Podurgiel, Lauren L. Long, Eric J. Nunes, Mercè Correa
    Pages 149-162
  8. Rui Daniel Prediger, Filipe Carvalho Matheus, Paulo Alexandre de Oliveira, Daniel Rial, Morgana Moretti, Ana Cristina Guerra de Souza et al.
    Pages 183-205
  9. Adriana Alexandre S. Tavares, Olivier Barret, John P. Seibyl, Gilles D. Tamagnan
    Pages 207-232
  10. Filipe B. Rodrigues, Daniel Caldeira, Joaquim J. Ferreira, João Costa
    Pages 233-272
  11. Emmanuelle Pourcher, Robert A. Hauser
    Pages 291-307
  12. Michael Lazarus, Yoshihiro Urade
    Pages 309-326
  13. Back Matter
    Pages 327-337

About this book


Adenosine A2A receptor antagonists have shown great promise in the treatment of Parkinson's Disease and alleviation of symptoms.  This book addresses various aspects of this class of drugs from their chemical development to their clinical use. Among the many insightful chapters contained in this book, there are three unique reviews that have not previously been published in any format: (1) a history of istradefylline, the first A2A antagonist approved for treatment of Parkinson's Disease, (2) an overview of neuroimaging studies in human health and disease, and (3) a study of urate as a possible biomarker and neuroprotectant.


Parkinson's disease adenosine A2A receptors neurodegeneration neuroimaging neuroinflammation neuroprotection

Editors and affiliations

  • Micaela Morelli
    • 1
  • Nicola Simola
    • 2
  • Jadwiga Wardas
    • 3
  1. 1.Dept. of Biomedical Sciences Section of NeuropsychopharmacologyUniversity of CagliariCagliariItaly
  2. 2.Dept. of Biomedical Sciences Section of NeuropsychopharmacologyUniversity of CagliariCagliariItaly
  3. 3.Dept. of Neuropsychopharmacology Institute of PharmacologyPolish Academy of SciencesKrakowPoland

Bibliographic information