A Guide to Numerical Modelling in Systems Biology

  • Peter Deuflhard
  • Susanna Röblitz

Part of the Texts in Computational Science and Engineering book series (TCSE, volume 12)

Table of contents

  1. Front Matter
    Pages i-x
  2. Peter Deuflhard, Susanna Röblitz
    Pages 1-32
  3. Peter Deuflhard, Susanna Röblitz
    Pages 33-87
  4. Peter Deuflhard, Susanna Röblitz
    Pages 89-138
  5. Back Matter
    Pages 139-176

About this book


This book is intended for students of computational systems biology with only a limited background in mathematics. Typical books on systems biology merely mention algorithmic approaches, but without offering a deeper understanding. On the other hand, mathematical books are typically unreadable for computational biologists. The authors of the present book have worked hard to fill this gap. The result is not a book on systems biology, but on computational methods in systems biology. This book originated from courses taught by the authors at Freie Universität Berlin. The guiding idea of the courses was to convey those mathematical insights that are indispensable for systems biology, teaching the necessary mathematical prerequisites by means of many illustrative examples and without any theorems. The three chapters cover the mathematical modelling of biochemical and physiological processes, numerical simulation of the dynamics of biological networks, and identification of model parameters by means of comparisons with real data. Throughout the text, the strengths and weaknesses of numerical algorithms with respect to various systems biological issues are discussed. Web addresses for downloading the corresponding software are also included.



mathematics in computational biology mathematics in systems biology numerical simulation parameter identification systems biological networks

Authors and affiliations

  • Peter Deuflhard
    • 1
  • Susanna Röblitz
    • 2
  1. 1.Zuse-Institut Berlin (ZIB)BerlinGermany
  2. 2.Zuse Institute Berlin (ZIB)BerlinGermany

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Mathematics and Statistics
  • Print ISBN 978-3-319-20058-3
  • Online ISBN 978-3-319-20059-0
  • Series Print ISSN 1611-0994
  • Series Online ISSN 2197-179X
  • Buy this book on publisher's site