Chromosomal Translocations and Genome Rearrangements in Cancer

  • Janet D. Rowley
  • Michelle M. Le Beau
  • Terence H. Rabbitts

Table of contents

  1. Front Matter
    Pages i-ix
  2. Introduction

  3. General

    1. Front Matter
      Pages 13-13
    2. Richard L. Frock, Jiazhi Hu, Frederick W. Alt
      Pages 27-51
    3. Yanwen Jiang, Isabelle Lucas, Michelle M. Le Beau
      Pages 73-94
    4. Henry Wood, Pamela Rabbitts
      Pages 95-104
  4. Leukaemia/Lymphoma

    1. Front Matter
      Pages 105-105
    2. Debora A. Casolari, Junia V. Melo
      Pages 107-138
    3. P. Leif Bergsagel, W. Michael Kuehl
      Pages 139-156
    4. Marco Fangazio, Laura Pasqualucci, Riccardo Dalla-Favera
      Pages 157-188
    5. Krzysztof Mrózek, Clara D. Bloomfield
      Pages 275-317
  5. Sarcomas

    1. Front Matter
      Pages 319-319
    2. Pierre Åman
      Pages 321-331
    3. Jason M. Tanner, Stephen L. Lessnick
      Pages 333-354
  6. Epithelial Tumours

    1. Front Matter
      Pages 355-355
    2. Maria Domenica Castellone, Giancarlo Vecchio
      Pages 357-380
    3. Andrew S. McDaniel, Scott A. Tomlins
      Pages 381-401
    4. Hiroyuki Mano
      Pages 403-416
    5. Paul T. Spellman
      Pages 417-426
  7. Other Aspects

    1. Front Matter
      Pages 427-427
    2. Katia Ruggero, Terence H. Rabbitts
      Pages 429-445
    3. Jacqueline M. Matthews
      Pages 447-466
    4. Constanze Bonifer, Peter N. Cockerill, Anetta Ptasinska
      Pages 467-484
  8. Back Matter
    Pages 485-490

About this book


This volume collates world experts’ insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible.


The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations, and which launched a field in cancer genetics.


Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours.

Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.


Cancer genomes Chromosomal abnormalities Chromosomal translocations Genome rearrangement Somatic mutation, Oncogenes

Editors and affiliations

  • Janet D. Rowley
    • 1
  • Michelle M. Le Beau
    • 2
  • Terence H. Rabbitts
    • 3
  1. 1.Dept. of Medicine, Section of Hematol./Oncol.University of ChicagoCHICAGOUSA
  2. 2.Section of Hematology/Oncology, Comprehensive Cancer CenterUniversity of ChicagoChicagoUSA
  3. 3.Weatherall Inst. of Molecular Medicine MRC Molecular Haematology UnitUniversity of OxfordOxfordUnited Kingdom

Bibliographic information