Pathogenesis, Diagnosis, Available Treatments, Drug Safety, Regenerative and Precision Medicine

  • Mohit Kapoor
  • Nizar N. Mahomed

Table of contents

  1. Front Matter
    Pages i-x
  2. Mohit Kapoor
    Pages 1-28
  3. Ivan Dzaja, Khalid Syed
    Pages 29-42
  4. Timothy Leroux, Christian Veillette
    Pages 43-60
  5. Y. Raja Rampersaud, Akihiro Nakamura, Stephen J. Lewis
    Pages 61-91
  6. Johnny Lau, Andrea N. Veljkovic, Patricia Farrugia
    Pages 93-109
  7. Herbert P. von Schroeder, Steven J. McCabe
    Pages 111-129
  8. Peter Salat, David Salonen, Andrea N. Veljkovic
    Pages 131-154
  9. Rachel Schachar, Darrell Ogilvie-Harris
    Pages 155-169
  10. Ying-Hua Li, Christopher Kim, Rajiv Gandhi
    Pages 171-189
  11. Camille Roubille, Jean-Pierre Pelletier, Johanne Martel-Pelletier
    Pages 191-210
  12. Anthony V. Perruccio, Vinod Chandran
    Pages 211-234
  13. Sowmya Viswanathan, Jesse Wolfstadt, Jaskarndip Chahal, Alejandro Gómez-Aristizábal
    Pages 235-255
  14. Christian J. H. Veillette, Igor Jurisica
    Pages 257-270
  15. Back Matter
    Pages 271-278

About this book


This comprehensive book grants readers exclusive insight into current advancements in the field of osteoarthritis (OA). Contributions from leading scientists and clinicians provide a detailed introduction into current understanding of the pathogenesis of OA, different joint structures affected by this debilitating disease (hip, knee, elbow, shoulder, foot, ankle, hand, wrist, and spine), current knowledge and practice in imaging, joint conservative strategies, OA biomarkers as well as currently available treatments, their safety profile and future therapeutic targets. This book further discusses the potential of regenerative therapies and recent advances in OA Personalized Medicine, and how collection of OA patients’ phenotypic, genetic and proteomic data is able to direct treatment strategies through Bio-Informatics.

Dr. Mohit Kapoor is an Associate Professor in the Department of Surgery and the Department of Laboratory Medicine and Pathobiology at the University of Toronto, Canada. He heads the cartilage biology research group within the Arthritis Program at the Toronto Western Research Institute, University Health Network, Toronto. His research program is directed towards understanding the complex pathophysiology of OA and identifying new therapeutic strategies to identify and counteract the destruction of the articular cartilage during OA. Specifically, his research is focused towards (a) understanding the mechanisms that are essential for maintaining articular cartilage homeostasis and mechanisms that trigger cell death and articular cartilage damage, and (b) identifying new OA biomarkers. Dr. Kapoor has published over 50 research articles, reviews and book chapters and is a recipient of several prestigious research awards.

Dr. Nizar Mahomed is head of the Division of Orthopaedic Surgery at the University Health Network and Professor in the Department of Surgery at the University of Toronto, Canada. He is Nicki and Bryce Douglas Chair and

Smith & Nephew Chair in Orthopaedic Surgery. Clinically he focuses on complex primary and revision hip and knee replacement surgery. He has over 100 publications and book chapters.  His research interests are in the areas of health systems research focusing on models of care for orthopaedic conditions and translational research looking at regenerative options for OA. Dr. Mahomed has received several awards for his research and is the recipient of the first CIHR-CMAJ Top Canadian Achievements in Health Research Award. As Medical Director of the Arthritis Program at University Health Network, he leads the largest integrated Arthritis Program in Canada.


Current knowledge and practice in imaging Future therapeutic targets Joint structures affected OA biomarkers Pathogenesis of OA

Editors and affiliations

  • Mohit Kapoor
    • 1
  • Nizar N. Mahomed
    • 2
  1. 1.Division of Genetics and DevelopmentToronto Western Research Institute, University Health Network and Department of Surgery, University of TorontoTorontoCanada
  2. 2.Division of OrthopaedicsToronto Western HospitalTorontoCanada

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Adis, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-19559-9
  • Online ISBN 978-3-319-19560-5
  • Buy this book on publisher's site