Animal Models of Ophthalmic Diseases

  • Chi-Chao Chan

Part of the Essentials in Ophthalmology book series (ESSENTIALS)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Robert L. Hendricks, Hongmin Yun, Alexander M. Rowe, Kate L. Carroll
    Pages 1-10
  3. Judith West-Mays, Scott Bowman
    Pages 11-29
  4. Thomas V. Johnson, Stanislav I. Tomarev
    Pages 31-50
  5. Mei Chen, Alan Stitt
    Pages 67-83
  6. Jennifer L. Kielczewski, Rachel R. Caspi
    Pages 85-100
  7. J. Paul Banga, Sajad Moshkelgosha, Utta Berchner-Pfannschmidt, Anja Eckstein
    Pages 117-126
  8. Martine J. Jager, Jinfeng Cao, Hua Yang, Didier Decaudin, Helen Kalirai, Wietske van der Ent et al.
    Pages 127-140
  9. Charles E. Egwuagu
    Pages 141-142
  10. Back Matter
    Pages 143-152

About this book


This book describes experimental animal models that mimic common human ocular diseases: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ disease, and intraocular tumors.  In conjunction, these models reflect the diversity and utility of tools used to study human disease.  World expert clinicians discuss each model based on their clinical experience, and the text is supported by numerous photos and diagrams. 

Development of suitable experimental models is critical in identifying risk factors for disease, elucidating fundamental molecular mechanisms in disease progression, and providing guidance as to whether or not a particular treatment is safe and effective for humans. Like other forms of medical research, ophthalmology and vision research focuses on the investigation of disease pathogenesis and the discovery of novel therapies through in vitro and in vivo methodology.  The in vivo experiments employ animal models including vertebrates (zebrafish, rodents, rabbits, and primates) and invertebrates (fruit flies and nematodes) for drug screening. In describing the most pertinent animal models of ophthalmic diseases, this book will be of interest to ophthalmologists, vision researchers, fellows, residents, and medical students.


Age-related Macular Degeneration Cataract Diabetic Retinopathy Glaucoma Intraocular Tumors

Editors and affiliations

  • Chi-Chao Chan
    • 1
  1. 1.Laboratory of ImmunologyNational Eye InstituteBethesdaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-19433-2
  • Online ISBN 978-3-319-19434-9
  • Series Print ISSN 1612-3212
  • Series Online ISSN 2196-890X
  • Buy this book on publisher's site