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The Male Role in Pregnancy Loss and Embryo Implantation Failure

  • Richard Bronson

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 868)

Table of contents

  1. Front Matter
    Pages i-x
  2. Benjamin J. Hale, Aileen F. Keating, Cai-Xia Yang, Jason W. Ross
    Pages 49-79
  3. Timothy G. Jenkins, Kenneth I. Aston, Tyson Meyer, Douglas T. Carrell
    Pages 81-93
  4. Anne Schumacher, Ana Claudia Zenclussen
    Pages 211-225
  5. Back Matter
    Pages 227-228

About this book

Introduction

Novel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors.

Keywords

Embryo implantation failure Paternal chromosomes Seminal fluid Seminal plasma Spermatozoa

Editors and affiliations

  • Richard Bronson
    • 1
  1. 1.Obstetrics, Gynecology, & Repro MedicineStony Brook University Medical Center T9-080Stony BrookUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-18881-2
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-18880-5
  • Online ISBN 978-3-319-18881-2
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site