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Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

  • Philip K. Moore
  • Matt Whiteman

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 230)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Biochemistry, Molecular Biology and Chemistry

    1. Front Matter
      Pages 1-1
    2. Caleb Weihao Huang, Philip Keith Moore
      Pages 3-25
  3. Molecular Mechanisms of Action

    1. Front Matter
      Pages 27-27
    2. Milos R. Filipovic
      Pages 29-59
  4. Cardiovascular and Urogenital Systems

    1. Front Matter
      Pages 83-83
    2. Guangdong Yang, Rui Wang
      Pages 85-110
    3. Roberta d’Emmanuele di Villa Bianca, Giuseppe Cirino, Raffaella Sorrentino
      Pages 111-136
  5. Inflammation and Inflammatory Disease

    1. Front Matter
      Pages 163-163
    2. Madhav Bhatia
      Pages 165-180
    3. Kotaro Kida, Fumito Ichinose
      Pages 181-189
  6. H2S and the Nervous System

    1. Front Matter
      Pages 191-191
  7. H2S, Angiogenesis and Cancer

    1. Front Matter
      Pages 231-231
    2. Mark R. Hellmich, Csaba Szabo
      Pages 233-241
    3. Zheng-Wei Lee, Lih-Wen Deng
      Pages 243-265
  8. H2S and Ageing

    1. Front Matter
      Pages 267-267
    2. Bedoor Qabazard, Stephen R. Stürzenbaum
      Pages 269-287
  9. H2S, Measurement and Possible Therapeutics?

    1. Front Matter
      Pages 289-289
    2. Wei Feng, Brian W. Dymock
      Pages 291-323
    3. Matthew Whiteman, Alexis Perry, Zongmin Zhou, Mariarosaria Bucci, Andreas Papapetropoulos, Guiseppe Cirino et al.
      Pages 337-363
    4. Yu Zhao, Armando Pacheco, Ming Xian
      Pages 365-388
  10. Back Matter
    Pages 389-395

About this book

Introduction

This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.

Keywords

biosynthesis disease hydrogen sulfide mechanisms molecular biology physiology

Editors and affiliations

  • Philip K. Moore
    • 1
  • Matt Whiteman
    • 2
  1. 1.National University of SingaporeSingaporeSingapore
  2. 2.ST. Luke's CampusUniversity of Exeter Medical SchoolExeterUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-18144-8
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-18143-1
  • Online ISBN 978-3-319-18144-8
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site