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Histone Recognition

  • Ming-Ming┬áZhou

Table of contents

  1. Front Matter
    Pages i-viii
  2. Jovylyn Gatchalian, Tatiana G. Kutateladze
    Pages 27-47
  3. Chao Xu, Gaofeng Cui, Maria Victoria Botuyan, Georges Mer
    Pages 49-82
  4. Jon R. Wilson, Neil Justin
    Pages 83-100
  5. Robert E. Collins, Xiaodong Cheng
    Pages 101-124
  6. Alexsandra Espejo, Mark T. Bedford
    Pages 125-147
  7. Haitao Li, Shuai Zhao, Dinshaw J. Patel
    Pages 149-172
  8. Panagis Filippakopoulos, Stefan Knapp
    Pages 173-183
  9. David F. Tough, Inmaculada Rioja, Rab K. Prinjha
    Pages 199-223
  10. Ryan J. Conrad, Daniela Boehm, Melanie Ott
    Pages 225-241
  11. Stephen V. Frye, Lindsey I. James
    Pages 243-271
  12. Back Matter
    Pages 273-282

About this book

Introduction

This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.

Keywords

Chromatin Control of gene expression Epigenetics Gene transcription Histone recognition Site-specific post-translational modifications

Editors and affiliations

  • Ming-Ming┬áZhou
    • 1
  1. 1.Department of Structural & Chemical BiologyIcahn School of Medicine at Mount SinaiNew YorkUSA

Bibliographic information