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Resistance to Aromatase Inhibitors in Breast Cancer

  • Alexey Larionov

Part of the Resistance to Targeted Anti-Cancer Therapeutics book series (RTACT, volume 8)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Debashis Ghosh, Jessica Lo, Chinaza Egbuta
    Pages 33-61
  3. Gauri Sabnis, Angela Brodie
    Pages 63-86
  4. Raffaella Maria Gadaleta, Luca Magnani
    Pages 145-168
  5. Abdul Aziz Bin Aiderus, Anita K. Dunbier
    Pages 169-190
  6. Alexey A. Larionov, William R. Miller
    Pages 191-228
  7. Back Matter
    Pages 287-288

About this book

Introduction

The book brings together current knowledge about molecular and clinical aspects of resistance to aromatase inhibitors (AIs). The topics and features include:

  • The history of development and clinical role of aromatase inhibitors in breast cancer.
  • The structure and function of aromatase gene and protein, including tissue-specific splicing and regulation of the gene, crystal structure of the enzyme, functioning of its active site and structural basis for development of new aromatase inhibitors.
  • Experimental and pre-clinical models of resistance to aromatase inhibitors (including cell lines and xenografts) as well as methods and results of measuring oestrogen concentrations in blood and tumour tissue of breast cancer patients.
  • Diversity of molecular mechanisms of AI resistance, including (i) ligand-independent signalling through oestrogen receptor pathway, (ii) hypersensitivity to low concentrations of oestrogens, (iii) crosstalk with non-endocrine signalling (including PI3K/mTOR, IGF, GDNF and Myc pathways), (iv) involvement of oestrogen-induced apoptosis and tissue microenvironment (including inflammatory immune cells and adipocytes) as well as (v) the role of epigenetic mechanisms and pioneering factors in ER signalling and AI resistance.
  • Molecular markers and multi-gene signatures to predict response to AIs, clinical trials aimed at preventing or overcoming resistance by combining AIs with novel targeted agents (including AI combinations with HER2, EGFR, mTOR, PI3K, Akt, CDK4/6, FGFR, HDAC, IGF-1, Src, proteosome- and angiogenic- targeting agents).
  • A review of the effects and clinical indications of aromatase inhibitors beyond breast cancer.

Many of the chapters provide extensive historical overviews to connect current knowledge with the history and inner logic of the field. The authors’ team includes world-leading experts, making the book an essential resource for scientists developing new treatments for breast cancer and for medics treating breast cancer patients with aromatase inhibitors.

Keywords

aromatase protein breast cancer estrogen receptor genetic polymorphism oestrogens

Editors and affiliations

  • Alexey Larionov
    • 1
  1. 1.Academic Laboratory of Medical Genetics, School of Clinical MedicineCancer Research UK Cambridge Institute, Statistics and Computational Biology Laboratory & University of CambridgeCambridgeUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-17972-8
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-17971-1
  • Online ISBN 978-3-319-17972-8
  • Series Print ISSN 2196-5501
  • Series Online ISSN 2196-551X
  • Buy this book on publisher's site