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Genomics, Personalized Medicine and Oral Disease

  • Stephen T. Sonis, DMD, DMSc

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Stephen T. Sonis
    Pages 1-10
  3. J. Robert Chang, Enkhtsetseg Purev, Winston Patrick Kuo
    Pages 11-34
  4. Ingrid Glurich, Sanjay Shukla, Amit Acharya, Geoffrey S. Ginsburg, Murray H. Brilliant
    Pages 35-65
  5. Manuela Moraru, Carlos Vilches
    Pages 67-90
  6. Elizabeth J. Leslie, Mary L. Marazita
    Pages 91-116
  7. John R. Shaffer, Mary L. Marazita
    Pages 117-144
  8. Arne S. Schäfer
    Pages 145-166
  9. Ricardo Carneiro Borra, Priscila Maria de Andrade
    Pages 167-183
  10. Nicola Luigi Bragazzi, Claudio Nicolini
    Pages 185-217
  11. Raman Mehrzad, Shawn Shetty, A. Razzaque Ahmed
    Pages 219-251
  12. Astrid Rasmussen, Christopher J. Lessard, Kathy L. Sivils
    Pages 253-272
  13. Chia-Cheng Li, Zhe Li, Reshma S Menon, Sook-Bin Woo
    Pages 273-292
  14. Srinivas Vinod Saladi, Leif W. Ellisen
    Pages 293-309
  15. Athanasios Zavras
    Pages 311-331
  16. Bruce J. Baum
    Pages 333-343
  17. Joel S. Greenberger, Michael W. Epperly, Peter Wipf, Song Li, Valerian Kagan, Xiang Gao
    Pages 345-362
  18. Kenneth S. Kornman, Gordon W. Duff, Kenneth Huttner, Peter J. Polverini, Jan Ching Chun Hu
    Pages 363-388
  19. Back Matter
    Pages 405-408

About this book

Introduction

The objective of this book is to catalyze the application of genomics to the diagnosis and treatment of oral diseases by comprehensively presenting focused discussions on the current state of knowledge. The first section of the book provides basic information about genetics, genomics, and personalized medicine and the informatical methods available to apply and organize genetic data so that it has clinical relevance. Recognizing the genetic robustness of the oral cavity, the introductory section includes chapters on the oral microbiome and host genomics and response to infectious agents. The next two sections contain chapters which describe the genomics of specific oral diseases and conditions, including the genetic basis for mechanism and risk of treatment toxicities associated with cancer therapy and bisphosphonates. Four chapters focus on gene-based therapies and the pharmacogenomics applied to oral disease. The final chapter presents a provocative summary which describes a comprehensive vision of the melding of genomics to personalized medicine and the potential actionable outcomes that will likely affect clinical practice in the upcoming years.​

Keywords

chromosome genomics oral disease personalized medicine pharmacogenomics

Editors and affiliations

  • Stephen T. Sonis, DMD, DMSc
    • 1
  1. 1.Brigham and Women’s HospitalBostonUSA

Bibliographic information