Cardiac Fibrosis and Heart Failure: Cause or Effect?

  • Ian M.C. Dixon
  • Jeffrey T. Wigle

Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 13)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Ian M.C. Dixon, Ryan H. Cunnington, Sunil G. Rattan, Jeffrey T. Wigle
    Pages 1-4
  3. Amit Saxena, Nikolaos G. Frangogiannis
    Pages 5-22
  4. Mark C. Blaser, Craig A. Simmons
    Pages 23-53
  5. Alison L. Müller, Darren H. Freed
    Pages 55-69
  6. Elena Zimina, Boris Hinz
    Pages 71-92
  7. R. Justin McCullough, Yao Sun, Kevin P. Newman, Kodangudi B. Ramanathan, Ramareddy V. Guntaka, Karl T. Weber
    Pages 93-107
  8. Michel Pucéat, Thomas Moore-Morris
    Pages 109-123
  9. Fahmida Jahan, Jeffrey T. Wigle
    Pages 125-145
  10. Matthew R. Zeglinski, Natalie M. Landry, Ian M. C. Dixon
    Pages 147-165
  11. Patricia L. Roche, Michael P. Czubryt
    Pages 181-217
  12. Fouad A. Zouein, Ashley DeCoux, Yuan Tian, Jared A. White, Yu-Fang Jin, Merry L. Lindsey
    Pages 237-259
  13. Christopher A. McCulloch, Nuno M. Coelho
    Pages 261-278
  14. Keith Dadson, Vera Kovacevic, Gary Sweeney
    Pages 279-297
  15. Holly E. M. Mewhort, Paul W. M. Fedak
    Pages 323-346
  16. Nirmal Parajuli, Tharmarajan Ramprasath, Pavel Zhabyeyev, Vaibhav B. Patel, Gavin Y. Oudit
    Pages 347-381
  17. Jacqueline S. Wendel, Robert. T. Tranquillo
    Pages 405-418
  18. Back Matter
    Pages 433-436

About this book


The unique biology of cardiac fibroblasts and related cells, such as cardiac myofibroblasts and valvular interstitial cells, distinguish them from other fibroblastic cells, a concept that is only beginning to be widely appreciated.  Further, the natural signals that stimulate and inhibit cardiac fibrosis within these cells are not well understood.  This volume compiles articles that address the molecular mechanisms that control the synthesis and secretion of the cardiac ECM.   The book showcases chapters that highlight discussion of role of Transforming Growth Factor β (TGFβ), an important fibrogenic cytokine, and its downstream effectors SMAD in many cardiac diseases. Further, the contributions highlight information to discuss endogenous inhibitors of cardiac fibrosis, as well as advances in tissue engineering specific to matrix in the heart. Finally, discussions of unifying mechanisms of matrix remodeling in valves and myocardium are presented. 

The mechanisms involved in the stimulation of cardiac fibrosis are not fully understood.  In most cases the marginal attenuation of cardiac fibrosis as a result of a given therapy is a beneficial side-effect linked to other primary effects on other cells, especially cardiomyocytes.  Very few drugs or agents are known to affect the function and dysfunction of cardiac fibroblasts and myofibroblasts alone.  The book helps to translate the information gathered within to allow us to alter the course of fibrogenic events that are typical of cardiac fibrosis, and thereby reduce their burden on the patient and on society itself.


Cardiac Fibrosis Myofibroblasts cardiac extracellular matrix cardiac fibroblasts microRNAs

Editors and affiliations

  • Ian M.C. Dixon
    • 1
  • Jeffrey T. Wigle
    • 2
  1. 1.Institute of Cardiovascular Sciences St. Boniface Hospital Research Centre Department of Physiology and PathophysiologyUniversity of ManitobaWinnipegCanada
  2. 2.Institute of Cardiovascular Sciences St. Boniface Hospital Research Centre Department of Biochemistry and Medical GeneticsUniversity of ManitobaWinnipegCanada

Bibliographic information