Murine Models, Energy Balance, and Cancer

  • Nathan A.┬áBerger

Part of the Energy Balance and Cancer book series (EBAC, volume 10)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Luciano DiTacchio, Kacee A. DiTacchio, Satchidananda Panda
    Pages 1-19
  3. Ellen Heber-Katz, Robert K. Naviaux
    Pages 47-64
  4. Darlene E. Berryman, Lara Householder, Vivian Lesende, Edward O. List, John J. Kopchick
    Pages 65-95
  5. Jonathan Tucci, Steven D. Mittelman
    Pages 97-116
  6. Stephen D. Hursting, Emily L. Rossi, Laura W. Bowers, Laura M. Lashinger
    Pages 117-125
  7. Praveena S. Thiagarajan, Ofer Reizes
    Pages 127-151
  8. Zara Zelenko, Derek LeRoith, Emily J. Gallagher
    Pages 153-174
  9. Hui-Hua Chang, Guido Eibl, Enrique Rozengurt
    Pages 197-215
  10. Back Matter
    Pages 293-295

About this book


This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment.


The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.


Mouse models epigenetic influences genetic engineering leptin obesity and cancer

Editors and affiliations

  • Nathan A.┬áBerger
    • 1
  1. 1.Center for Science, Health & SocietyCase Western Reserve University School of MedicineClevelandUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-16732-9
  • Online ISBN 978-3-319-16733-6
  • Series Print ISSN 2199-2622
  • Series Online ISSN 2199-2630
  • Buy this book on publisher's site