Pathophysiology of Headaches

From Molecule to Man

  • Messoud Ashina
  • Pierangelo Geppetti

Part of the Headache book series (HEAD)

Table of contents

  1. Front Matter
    Pages i-x
  2. Hayrunnisa Bolay, Karl Messlinger, Mária Dux, Didem Akcali
    Pages 1-29
  3. Anna P. Andreou, Michael L. Oshinsky
    Pages 31-66
  4. Cristina Tassorelli, Rosaria Greco, Simon Akerman
    Pages 67-82
  5. Cherubino Di Lorenzo, Filippo M. Santorelli, Arn M. J. M. van den Maagdenberg
    Pages 83-99
  6. Henrik Winther Schytz, Guus G. Schoonman
    Pages 101-115
  7. Michaela Andelova, David Borsook, Till Sprenger
    Pages 117-136
  8. Sarah Miller, Manjit S. Matharu
    Pages 137-153
  9. Gianluca Coppola, Francesco Pierelli, Petter M. Omland, Trond Sand
    Pages 155-174
  10. Anna Ambrosini, Gianluca Coppola
    Pages 175-183
  11. Paola Sarchielli, Stefano Caproni, Cinzia Costa, Delia Szok, Janos Tajti
    Pages 185-215
  12. Jakob Møller Hansen, Dan Levy
    Pages 217-234
  13. Sait Ashina, Lars Bendtsen
    Pages 235-246

About this book


This book provides a detailed overview of the current state of knowledge regarding the pathophysiology of both primary headaches – migraine, tension-type headache (TTH), and cluster headache – and the very important and frequent type of secondary headache, medication overuse headache (MOH). After an introductory chapter describing relevant neuroanatomy and vascular anatomy, the evidence gained from animal models regarding the pathophysiology of migraine and the other primary headaches is reviewed. Knowledge of the genetic component in the different types of headache is then examined with reference to recent evidence, for example regarding the implication of the trigeminovascular system and cortical spreading depression in migraine. Detailed information is provided on insights into primary headaches from imaging studies, including functional magnetic resonance imaging and positron emission tomography and on their neurophysiology and biochemistry. A further series of important chapters describe present knowledge of the pathophysiology of each specific type of headache and consider future directions. Written by acknowledged experts in their fields from Europe and the United States, clinicians and students will find Pathophysiology of Headaches to be an excellent source of up-to-date information on why patients experience headaches. In addition, it will be of value for pain researchers investigating the underlying mechanisms of headache.


Biochemistry of headache Cluster headache Imaging of headache Medication overuse headache Neurophysiology of migraine Tension-type headache

Editors and affiliations

  • Messoud Ashina
    • 1
  • Pierangelo Geppetti
    • 2
  1. 1.Department of NeurologyDanish Headache Center Rigshospitalet and Glostrup HospitalGlostrupDenmark
  2. 2.Department of Health SciencesUniversity of FlorenceFlorenceItaly

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-15620-0
  • Online ISBN 978-3-319-15621-7
  • Series Print ISSN 2197-652X
  • Series Online ISSN 2197-6538
  • Buy this book on publisher's site