Cytochrome P450

Structure, Mechanism, and Biochemistry

  • Paul R.¬†Ortiz de Montellano

Table of contents

  1. Front Matter
    Pages i-x
  2. Volume 1

    1. Front Matter
      Pages 1-1
    2. Thomas L. Poulos, Eric F. Johnson
      Pages 3-32
    3. Lucy Waskell, Jung-Ja P. Kim
      Pages 33-68
    4. Ilia G. Denisov, Stephen G. Sligar
      Pages 69-109
    5. Paul R. Ortiz de Montellano
      Pages 111-176
    6. Maria Almira Correia, Paul. F. Hollenberg
      Pages 177-259
    7. Kirsty J. McLean, David Leys, Andrew W. Munro
      Pages 261-407
    8. Marco Girhard, Patrick J. Bakkes, Osama Mahmoud, Vlada B. Urlacher
      Pages 451-520
  3. Volume 2

    1. Front Matter
      Pages 521-521
    2. F. Peter Guengerich
      Pages 523-785
    3. Saki Gotoh, Marumi Ohno, Kouichi Yoshinari, Masahiko Negishi, Kaname Kawajiri
      Pages 787-812
    4. David J. Waxman, Thomas K. H. Chang
      Pages 813-850
    5. Richard J. Auchus, Walter L. Miller
      Pages 851-879
    6. Matthew L. Edin, Jennifer Cheng, Artiom Gruzdev, Samantha L. Hoopes, Darryl C. Zeldin
      Pages 881-905
  4. Back Matter
    Pages 907-912

About this book


This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems.


Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.


Cytochrome P450 drug metabolism enzyme mechanism hemoprotein function lipid metabolism protein structure sterol biogenesis

Editors and affiliations

  • Paul R.¬†Ortiz de Montellano
    • 1
  1. 1.University of California, San FranciscoSan FranciscoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-12107-9
  • Online ISBN 978-3-319-12108-6
  • Buy this book on publisher's site