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Transcriptomics in Health and Disease

  • Geraldo A. Passos

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Basic Principles of the Transcriptome and Its Analysis

    1. Front Matter
      Pages 1-1
    2. Amanda F. Assis, Ernna H. Oliveira, Paula B. Donate, Silvana Giuliatti, Catherine Nguyen, Geraldo A. Passos
      Pages 3-48
    3. Tainá Raiol, Daniel Paiva Agustinho, Kelly Cristina Rodrigues Simi, Calliandra Maria de Souza Silva, Maria Emilia Walter, Ildinete Silva-Pereira et al.
      Pages 49-68
    4. Patricia Severino, Elisa Napolitano Ferreira, Dirce Maria Carraro
      Pages 69-78
    5. Carlos Alberto Moreira-Filho, Silvia Yumi Bando, Fernanda Bernardi Bertonha, Filipi Nascimento Silva, Luciano da Fontoura Costa
      Pages 79-94
    6. Bruno Dallagiovanna, Fabiola Holetz, Patricia Shigunov
      Pages 95-107
    7. Karina F. Bombonato-Prado, Adalberto L. Rosa, Paulo T. Oliveira, Janaína A. Dernowsek, Vanessa Fontana, Adriane F. Evangelista et al.
      Pages 109-119
  3. Transcriptome in Disease

    1. Front Matter
      Pages 121-121
    2. Carlos Alberto Moreira-Filho, Silvia Yumi Bando, Fernanda Bernardi Bertonha, Filipi Nascimento Silva, Luciano da Fontoura Costa, Magda Carneiro-Sampaio
      Pages 123-136
    3. Cristhianna V. A. Collares, Eduardo A. Donadi
      Pages 137-159
    4. Paula Takahashi, Danilo J. Xavier, Elza T. Sakamoto-Hojo
      Pages 161-180
    5. Adriane F. Evangelista, Marcia M. C. Marques
      Pages 181-193
    6. Renê Donizeti Ribeiro de Oliveira, Paulo Louzada-Júnior
      Pages 195-209
    7. Olga Martinez Ibañez, José Ricardo Jensen, Marcelo De Franco
      Pages 211-226
    8. Nalu T. A. Peres, Gabriela F. Persinoti, Elza A. S. Lang, Antonio Rossi, Nilce M. Martinez-Rossi
      Pages 227-263
    9. Patrícia Albuquerque, Hugo Costa Paes, Aldo Henrique Tavares, Larissa Fernandes, Anamélia Lorenzetti Bocca, Ildinete Silva-Pereira et al.
      Pages 265-287
    10. Rodrigo Ferracine Rodrigues, Rogério Silva Rosada, Thiago Malardo, Wendy Martin Rios, Celio Lopes Silva
      Pages 289-310
    11. Ludmila Rodrigues P. Ferreira, Edecio Cunha-Neto
      Pages 311-325
  4. Back Matter
    Pages 341-344

About this book

Introduction

After sequencing the human genome a decade ago, researchers have continued their projects, but now to try to better understand how, and when, genes are expressed in health and disease. Efforts have been concentrated on the measurement of the expression of RNA transcripts. In an analogy to the genome, the term "transcriptome" was created to refer to the complete set of RNAs in a cell type or tissue in a particular situation. Transcriptomics is the science that studies this issue and it is a branch of functional genomics. Transcriptomics in Heath and Disease provides a comprehensive overview of the science of transcriptomics initially in health, focusing on the concept of the transcriptome and the main methods to evaluate it. The authors discuss the concept and use of gene expression signatures and transcriptional biomarkers in normal development and diseased tissues and organs. As the transcriptome changes depending on the pathology, there is also a focus on the variations in the gene expression in different diseases such as autoimmune, inflammation, cancer and infections. This book should be very useful for researchers in molecular biology focusing on gene expression, human genetics, immunology, and genomics.

Keywords

RNA gene expression genomics health and disease transcriptomics

Editors and affiliations

  • Geraldo A. Passos
    • 1
  1. 1.Department of GeneticsUniversity of São PauloRibeirão PretoBrazil

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