Mechanisms of Circadian Systems in Animals and Their Clinical Relevance

  • Raúl Aguilar-Roblero
  • Mauricio Díaz-Muñoz
  • Mária Luisa Fanjul-Moles

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Circadian Systems

    1. Front Matter
      Pages 13-13
    2. Vincent M. Cassone
      Pages 69-96
    3. Christiane Andressa da Silva, Carolina Carrijo, Kathiane Santana, John Fontenele Araujo
      Pages 97-112
  3. Mechanisms of Circadian Oscillation

    1. Front Matter
      Pages 113-113
    2. Raúl Aguilar-Roblero, Mauricio Díaz-Muñoz, Adrian Báez-Ruíz, Daniel Quinto-Muñoz, Gabriella Lundkvist, Stephan Michel
      Pages 115-132
    3. Charles N. Allen, Nathan J. Klett, Robert P. Irwin, Mykhaylo G. Moldavan
      Pages 133-148
    4. Elvira Morgado, Claudia Juárez-Portilla, Ann-Judith Silverman, Rae Silver
      Pages 149-175
    5. Mario Caba, Stefan Waliszewski, Enrique Meza
      Pages 177-195
    6. Horacio O. de la Iglesia, Michael L. Lee
      Pages 197-217
  4. Clinical Relevance of Circadian Rhythmicity

    1. Front Matter
      Pages 219-219
    2. Raúl Aguilar-Roblero
      Pages 221-236
    3. Yu Tahara, Shigenobu Shibata
      Pages 237-260
    4. Manuel Miranda-Anaya, Christian Molina-Aguilar, Olivia Vázquez-Martínez, Mauricio Díaz-Muñoz
      Pages 261-287
    5. Juan J. Chiesa, José M. Duhart, Leandro P. Casiraghi, Natalia Paladino, Ivana L. Bussi, Diego A. Golombek
      Pages 289-320
    6. Dika Kuljis, Analyne M. Schroeder, Takashi Kudo, Dawn H. Loh, Christopher S. Colwell
      Pages 321-338
    7. Gabriela Domínguez-Monzón, José Segovia
      Pages 339-350
  5. Back Matter
    Pages 351-380

About this book


Well known experts in the field of Chronobiology from around the world, provide an integrative view of the state of the art of circadian biology. At present, genetic and epigenetic interaction of regulatory pathways among circadian oscillators, metabolic networks, cellular differentiation and neuronal communication are subject of intense scrutiny. The book is organized in three sections: The first includes selected examples of the circadian systems of crustaceans, insects, fish, birds and mammals. The second is a detailed view of the physiological mechanisms underlying the circadian clocks in mammals. Finally, in the third section some examples of the relevance of circadian biology and circadian misalignment to health and disease are provided including nutrition and metabolism, obesity, cancer, cardiovascular and pulmonary diseases, Huntington and affective diseases. This section concludes with a brief review on gene therapy and its potential use as a therapeutic tool to correct “clock genes” pathologies.

This book is aimed at all those interested in contemporary aspects of physiology, biochemistry and molecular biology applied to the study and characterization of timing systems.. It could be used as an initial approach to this field, but it also provides updated information for those already familiar with the fascinating field of Chronobiology.


Biological rhythms Chronobiology Chronotherapy Circadian systems Clock genes Integrative physiology

Editors and affiliations

  • Raúl Aguilar-Roblero
    • 1
  • Mauricio Díaz-Muñoz
    • 2
  • Mária Luisa Fanjul-Moles
    • 3
  1. 1.Instituto de Fisiología CelularUniversidad Nacional Autonoma de MéxicoMéxicoMexico
  2. 2.Instituto de NeurobiologíaUniversidad Nacional Autónoma de MéxicoJuriquillaMexico
  3. 3.Facultad de CienciasUniversidad Nacional Autónoma de MéxicoMéxicoMexico

Bibliographic information