Glutamate and ATP at the Interface of Metabolism and Signaling in the Brain

  • Vladimir Parpura
  • Arne Schousboe
  • Alexei Verkhratsky

Part of the Advances in Neurobiology book series (NEUROBIOL, volume 11)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Alexei Verkhratsky, Arne Schousboe, Vladimir Parpura
    Pages 1-12
  3. Arne Schousboe, Susanna Scafidi, Lasse K. Bak, Helle S. Waagepetersen, Mary C. McKenna
    Pages 13-30
  4. Leif Hertz, Junnan Xu, Liang Peng
    Pages 31-54
  5. Alexei Verkhratsky, Geoffrey Burnstock
    Pages 55-79
  6. Christina L. Ruby, Katheryn M. O’Connor, Jennifer Ayers-Ringler, Doo-Sup Choi
    Pages 103-119
  7. Naomi L. Sayre, Yanan Chen, Mikaela Sifuentes, Brian Stoveken, James D. Lechleiter
    Pages 121-150
  8. Yi-Bing Ouyang, Lijun Xu, Siwei Liu, Rona G. Giffard
    Pages 171-188
  9. Heike Franke, Peter Illes
    Pages 213-256
  10. Back Matter
    Pages 257-261

About this book


ATP was naturally selected very early on as the main source of biological energy, and thus became an indispensable feature of life on the Earth. This was a critical evolutionary choice because it shaped enzymatic systems to utilize ATP in energy-dependent reactions and necessitated an appearance of the universal intracellular signaling system based on calcium ions; keeping cytosolic Ca2+ extremely low became vitally important, since otherwise insoluble Ca2+-phosphates would preclude the cell energetics. Thus, all living cells on the Earth, beginning from the most primitive ones, had high cytosolic concentrations of ATP and there is little surprise that ATP was soon utilized by nature for another fundamental function of sending information from one living cell to another. In summary, ATP acts as the main energy source and is pivotal for numerous signaling cascades both inside (by fueling various transport systems and donating phosphate groups) and between the cells (by chemical transmission). Similarly, glutamate acts as an important molecule for both intercellular signaling through glutamatergic transmission and cell energetics by contributing to ATP production.

In this collection of chapters, written by the leading experts in the fields of cell metabolism and energetics, intracellular signaling and neurotransmission, we covered various aspects of the interfacing between these two fundamental molecules. This book will be particularly useful for researchers, students, physicians and psychotherapists working in the field of neurobiology, neurology and psychiatry.


Glial cells Metabolism Signaling

Editors and affiliations

  • Vladimir Parpura
    • 1
  • Arne Schousboe
    • 2
  • Alexei Verkhratsky
    • 3
  1. 1.Department of Neurobiology CIRC 429University of AlabamaBirminghamUSA
  2. 2.Faculty of Health and Medical Sciences, Department of Drug Design and PharmacologyUniversity of CopenhagenCopenhagenDenmark
  3. 3.Faculty of Life SciencesThe University of ManchesterManchesterUnited Kingdom

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-08893-8
  • Online ISBN 978-3-319-08894-5
  • Series Print ISSN 2190-5215
  • Series Online ISSN 2190-5223
  • Buy this book on publisher's site