Mathematical Modelling of Chromosome Replication and Replicative Stress

  • Jens┬áKarschau

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Jens Karschau
    Pages 1-18
  3. Jens Karschau
    Pages 75-76

About this book


DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next, and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive.
This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome; and how is the spatial organization of replication factories achieved inside the nucleus of a cell?
A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.


DNA Replication Factory DNA Replication Mechanisms DNA Replication Modelling DNA Replication Timing DNA Replication and Cancer Embryogenesis and Development Interaction of Replication Forks Origin of Replication Random Completion Problem Random Gap Problem Replication Starting Points

Authors and affiliations

  • Jens┬áKarschau
    • 1
  1. 1.Biological Physics DivisionMax Planck Institute for the Physics of Complex SystemsDresdenGermany

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-3-319-08860-0
  • Online ISBN 978-3-319-08861-7
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
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