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© 2015

ADAMTS13

Biology and Disease

  • George M. Rodgers
Book

Table of contents

  1. Front Matter
    Pages i-x
  2. Suneel S. Apte
    Pages 21-37
  3. X. Long Zheng
    Pages 39-57
  4. Manfai Lee, George M. Rodgers
    Pages 59-72
  5. Yoshihiro Fujimura, Koichi Kokame, Hideo Yagi, Ayami Isonishi, Masanori Matsumoto, Toshiyuki Miyata
    Pages 73-90
  6. Kristi J. Smock, Nahla M. Heikal
    Pages 141-158
  7. Silvia Ferrari, Hanspeter Rottensteiner, Friedrich Scheiflinger
    Pages 159-184
  8. Back Matter
    Pages 185-186

About this book

Introduction

This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility.

 

Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.

Keywords

Angiogenesis Protease Thrombosis Upshaw-Schulman Von Willebrand

Editors and affiliations

  • George M. Rodgers
    • 1
  1. 1.Division of HematologyUniversity of Utah Health Sciences CenterSalt Lake CityUSA

About the editors

Dr. George M. Rodgers received his M.D. and Ph.D. in Pharmacology from Tulane University Medical School in New Orleans, Louisiana. He completed his internal medicine training at Baylor College of Medicine in Houston, Texas, along with a hematology fellowship at the University of California, San Francisco, and served on the UCSF faculty. He is currently Professor of Medicine and Pathology at the University of Utah Medical Center in Salt Lake City and Medical Director of the Coagulation Laboratory at ARUP Laboratories. Dr. Rodgers is board certified in internal medicine, hematology and hematopathology. His clinical interests are in benign hematology, particularly coagulation disorders, and his basic research interests are in vascular biology, especially endothelial cell regulation of hemostasis. A current project is studying the role of ADAMTS13 in angiogenesis.

Bibliographic information

Reviews

“The purpose is to provide a current overview of ADAMTS13, spanning basic science and clinical medicine. … of interest to any medical students, residents, practicing physicians, or allied health practitioners involved in the care of these patients. … If you are even remotely interested in ADAMTS13, you must get this book. This is most certainly one of the best current reviews of this subject available today.” (Valerie L. Ng, Doody’s Book Reviews, November, 2015)