Handbook of Chronic Myeloid Leukemia

  • Timothy P Hughes
  • David M Ross
  • Junia V Melo

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Timothy P Hughes, David M Ross, Junia V Melo
    Pages 1-8
  3. Timothy P Hughes, David M Ross, Junia V Melo
    Pages 9-19
  4. Timoth P. Hughes, David M. Ross, Junia V. Melo
    Pages 21-33
  5. Timothy P. Hughes, David M. Ross, Junia V. Melo
    Pages 35-51
  6. Timothy P. Hughes, David M. Ross, Junia V. Melo
    Pages 53-65

About this book


This concise, clinically focused pocket handbook assembles and synthesizes the latest developments and trends in the diagnosis and treatment of CML and provides an authoritative and convenient summary of the latest progress in TKI trials, the molecular monitoring of CML responses, and the development of new therapies to overcome resistance and improve patient care. Chronic myeloid leukemia (CML) is a rare type of leukemia (1–2 per 100,000 people) but is the most common chronic myeloproliferative neoplasm. CML remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level; CML was the first cancer to be associated with a recurring chromosome abnormality, which generates the Philadelphia (Ph) chromosome and its associated fusion gene BCR-ABL1. The clinical outcome for patients with CML has changed dramatically in the past 15 years and this has been due to the development of tyrosine kinase inhibitors (TKIs), compounds that inhibit the activity of the oncogenic BCR-ABL1 protein. A number of first-, second- and third-generation TKIs are now available for the treatment of CML, although a number of treatment challenges remain, not least the development of treatment-resistant CML. Parallel to the development of specific drugs for treating CML, major advances have been made in the field of disease monitoring and standardization of response criteria. 


BCR-ABL signaling Hematology Leukemia Tyrosine kinase inhibitors

Authors and affiliations

  • Timothy P Hughes
    • 1
  • David M Ross
    • 2
  • Junia V Melo
    • 3
  1. 1.Department of HematologySA Pathology & SAHMRI, University of AdelaideAdelaideAustralia
  2. 2.Department of HaematologyFlinders University and Medical Centre and School of Medicine, University of AdelaideAdelaideAustralia
  3. 3.University of Adelaide, Department of HaematologyAdelaideAustralia

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Adis, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-08349-0
  • Online ISBN 978-3-319-08350-6
  • Buy this book on publisher's site