The UNC-53-mediated Interactome

Analysis of its Role in the Generation of the C. elegans Connectome

  • Amita Pandey
  • Girdhar K. Pandey

Part of the SpringerBriefs in Neuroscience book series (BRIEFSNEUROSCI)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Amita Pandey, Girdhar K. Pandey
    Pages 1-7
  3. Amita Pandey, Girdhar K. Pandey
    Pages 47-71

About this book


This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders.​

In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The adaptor protein UNC-53 appears to play a part in migration along the AP axis in both worms and their human homologs. “Neuron Navigators” (NAV) are also involved in nervous system development 


C. elegans interactome axon and cell migragion connectome develoment of the nervous system downstream signaling pathways neural disorders

Authors and affiliations

  • Amita Pandey
    • 1
  • Girdhar K. Pandey
    • 2
  1. 1.Plant Molecular BiologyDelhi University South CampusNew DelhiIndia
  2. 2.Department of Plant Molecular BiologyUniversity of Delhi South CampusDhaula KuanIndia

Bibliographic information

  • DOI
  • Copyright Information The Author(s) 2014
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-07826-7
  • Online ISBN 978-3-319-07827-4
  • Series Print ISSN 2191-558X
  • Series Online ISSN 2191-5598
  • Buy this book on publisher's site