Biopsy Diagnosis of Peripheral Neuropathy

1. Front Matter

   Pages i-xxi

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2. Peripheral Neuropathy and the Role of Nerve Biopsy

   • Juan M. Bilbao, Robert E. Schmidt

   Pages 1-20

3. Normal Anatomy of the Peripheral (Sural) Nerve

   • Juan M. Bilbao, Robert E. Schmidt

   Pages 21-41

4. Quantitative Techniques

   • Juan M. Bilbao, Robert E. Schmidt

   Pages 43-50

5. The Axon: Normal Structure and Pathological Alterations

   • Juan M. Bilbao, Robert E. Schmidt

   Pages 51-84

6. Schwann Cells and Myelin in the Peripheral Nervous System

   • Juan M. Bilbao, Robert E. Schmidt

   Pages 85-109

7. The Peripheral Nerve Vasculature

   • Juan M. Bilbao, Robert E. Schmidt

   Pages 111-122

8. Examination of the Peripheral Nerve Biopsy

   • Juan M. Bilbao, Robert E. Schmidt

   Pages 123-149

9. Clinical Aspects of Peripheral Neuropathy

   • Juan M. Bilbao, Robert E. Schmidt

   Pages 151-159

10. The Inflammatory Demyelinating Neuropathies

    • Juan M. Bilbao, Robert E. Schmidt

    Pages 161-196

11. Idiopathic Inflammatory Neuropathies

    • Juan M. Bilbao, Robert E. Schmidt

    Pages 197-207

12. Infectious Diseases Causing Neuropathy

    • Juan M. Bilbao, Robert E. Schmidt

    Pages 209-224

13. Leprous Neuropathy

    • Juan M. Bilbao, Robert E. Schmidt

    Pages 225-243

14. Vasculitic Neuropathy

    • Juan M. Bilbao, Robert E. Schmidt

    Pages 245-271

15. Dysproteinemic Neuropathies

    • Juan M. Bilbao, Robert E. Schmidt

    Pages 273-293

16. Amyloid Neuropathy

    • Juan M. Bilbao, Robert E. Schmidt

    Pages 295-309

17. Neuropathy Associated with Neoplasia

    • Juan M. Bilbao, Robert E. Schmidt

    Pages 311-330

18. Neuropathy Associated with Endocrine and Metabolic Disease

    • Juan M. Bilbao, Robert E. Schmidt

    Pages 331-354

19. Toxic Neuropathies

    • Juan M. Bilbao, Robert E. Schmidt

    Pages 355-374

20. Genetically Determined Neuropathies

    • Juan M. Bilbao, Robert E. Schmidt

    Pages 375-428

Peripheral nerve analysis is a challenging task for pathologists, given the advent of new diagnoses and techniques of analysis and the impact of molecular genetics. This book presents a simple, logical method for constructing a differential diagnosis based on pathology and clinical presentation. It also provides advice on the selection of ancillary molecular, immunohistochemical and genetic techniques to establish a definitive diagnosis. Clear, authoritative guidance is offered on diagnosis of the full range of neuropathies with the aid of a wealth of high-quality color photomicrographs and electron micrographs. The pathologist will benefit greatly from the identification of a variety of artifacts and normal structures occasionally encountered in nerve biopsies that need to be distinguished from specific pathologic alterations. This user-friendly, practical text will be an invaluable aid in achieving the most specific diagnosis possible.

• Autonomic Pathology
• Axonopathy
• Demyelination
• Painful Neuropathy
• Toxins

From the book reviews:

“This book presents a simple, logical method for constructing a differential diagnosis of peripheral nerve disease based on pathology and clinical presentation. … The intended audience is pathologists, neurologists, and neuroscientists in training, but the book is also appropriate for pathology residents and neuropathology fellows, as well as neuroscientists. … This user-friendly, practical book will be an invaluable aid in achieving the most specific diagnosis possible.” (Arlette Habashi, Doody’s Book Reviews, April, 2015)

• Professor Emeritus of Neuropathology, Sunnybrook and St Michael’s Hospitals, University of Toronto, Toronto, Canada

  Juan M Bilbao

• Professor of Pathology and Immunology, Director, Division of Neuropathology, Department of Pathology, Washington University School of Medicine, St. Louis, USA

  Robert E Schmidt

Robert E. Schmidt, MD, PhD, graduated from Washington University School of Medicine and has since spent his entire career at the School. For the past two decades he has been Director of the Division of Neuropathology and Professor of Pathology and in 2006 he was also appointed Director of the Research Electron Microscopy Core Laboratory. Dr. Schmidt is the recipient of various honors and awards and is a member of the Alpha Omega Alpha Honor Medical Society. He is a longstanding member of the editorial board of the Journal of Neuropathology and Experimental Neurology and since 2007 has been Senior Editor of Brain Pathology. Dr. Schmidt is the lead or co-author of 140 articles in peer-reviewed journals, as well as many reviews and other publications. Juan M. Bilbao, MD, graduated from Universidad Nacional de la Plata, Argentina and then undertook residencies in Boston and Montreal. He received his certification in Neuropathology from the American Board of Pathology in 1972 and the Royal College of Physicians and Surgeons of Canada in 1973. Dr. Bilbao has been an Associate Professor in Laboratory Medicine and Pathobiology at the University of Toronto since 1997 and Consultant Neuropathologist at the Toronto Hospital Corporation since 1998. He is also now Associate Pathologist (Neuropathology) at St. Michael’s Hospital, Toronto. Dr. Bilbo is a past Chief Examiner, Section of Neuropathology, for the Royal College of Physicians and Surgeons of Canada. He is the author of 124 articles in peer-reviewed journals and numerous other publications.

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