Dissecting Regulatory Interactions of RNA and Protein

Combining Computation and High-throughput Experiments in Systems Biology

  • Marvin┬áJens

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Marvin Jens
    Pages 1-19
  3. Marvin Jens
    Pages 21-33
  4. Marvin Jens
    Pages 81-86
  5. Marvin Jens
    Pages 87-98
  6. Back Matter
    Pages 99-99

About this book


The work described in this book is an excellent example of interdisciplinary research in systems biology. It shows how concepts and approaches from the field of physics can be efficiently used to answer biological questions, and reports on a novel methodology involving creative computer-based analyses of high-throughput biological data. Many of the findings described in the book, which are the result of collaborations between the author (a theoretical scientist) and experimental biologists, and between different laboratories, have been published in high-quality peer-reviewed journals such as Molecular Cell and Nature. However, while those publications address different aspects of post-transcriptional gene regulation, this book provides readers with a complete, coherent and logical view of the research project as a whole. The introduction presents post-transcriptional gene regulation from a distinct angle, highlighting aspects of information theory and evolution, and laying the groundwork for the questions addressed in the subsequent chapters, which concern the regulation of the transcriptome as the primary functional carrier of active genetic information.


Binding site occupancy CDR1as Competing RNA ELAVL1 HuR Model of ELAVL1 binding PAR-CLIP clusters and filtering PAR-CLIP computational pipeline Post-transcriptional regulation RNA competition theory RNA-binding proteins Sponge RNA circRNA detection from sequencing data miR-7 sponge

Authors and affiliations

  • Marvin┬áJens
    • 1
  1. 1.Max Delbrueck Center for Molecular Medicine, Systems Biology of Gene Regulatory ElementsBerlin Institute for Medical Systems Biology (BIMSB)BerlinGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-07082-7
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Engineering
  • Print ISBN 978-3-319-07081-0
  • Online ISBN 978-3-319-07082-7
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • About this book