Spectroscopic and Mechanistic Studies of Dinuclear Metallohydrolases and Their Biomimetic Complexes

  • Lena Josefine Daumann
Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Lena Josefine Daumann
    Pages 1-12
  3. Lena Josefine Daumann
    Pages 13-64
  4. Lena Josefine Daumann
    Pages 237-239

About this book

Introduction

Lena Daumanns's thesis describes structural and functional studies of the enzyme Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. It also examines the properties of small mimics of this enzyme and related binuclear metallohydrolases such as the metallo-ß-lactamases to enhance our understanding of hydrolytic cleavage of important substrates like phosphoesters and β-lactams. Overall, this project has led to a better understanding of the metal ion binding and active site structural features of the enzyme GpdQ. Daumann describes how she successfully immobilized phosphoesterase and related biomimetics on solid supports for potential applications in the area of bioremediation of organophosphate pesticides. Analysis shows that both the enzyme and biomimetics can be stored on the solid support without loss of activity. Furthermore, the author specroscopically and mechanistically characterized a number of Zn(II), Cd(II) and Co(II) complexes, some of which are among the most active biomimetics towards organophosphates reported to date. This thesis makes excellent reading for non-specialists because each chapter includes a short introduction section.

Keywords

Antibiotic Resistance Bioinspired Hydrolysis Biomimetic Complex Dinuclear Cobalt Complexes Magnetism Magnetic Circular Dichrosim Metallo-beta-lactamase Organophosphate Pesticide Bioremediation Phosphoesterase Enzymes

Authors and affiliations

  • Lena Josefine Daumann
    • 1
  1. 1.School of Chemistry and Molecular BiosciencesUniversity of QueenslandBrisbaneAustralia

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-06629-5
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-06628-8
  • Online ISBN 978-3-319-06629-5
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • About this book