Peptide and Protein Interaction with Membrane Systems

Applications to Antimicrobial Therapy and Protein Drug Delivery

  • Sara┬áBobone
Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Antimicrobial Peptides: Mechanism of Action, Selectivity and Biological Activity

    1. Front Matter
      Pages 1-1
    2. Sara Bobone
      Pages 3-10
    3. Sara Bobone
      Pages 11-17
    4. Sara Bobone
      Pages 19-27
    5. Sara Bobone
      Pages 29-90
  3. Hydrogel Nanoparticles for Enzyme-Based Therapies

    1. Front Matter
      Pages 91-91
    2. Sara Bobone
      Pages 93-102
    3. Sara Bobone
      Pages 103-110
    4. Sara Bobone
      Pages 111-133
  4. Back Matter
    Pages 135-140

About this book

Introduction

In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria. Bobone shows that AMPs interact with liposomes and she clarifies the structure of pores formed by one of these molecules. These results help us to understand how AMPs are selective for bacterial membranes and how their activity can be finely tuned by modifying their sequence. Findings which solve several conundrums debated in the literature for years. In addition, Bobone uses liposomes as nanotemplates for the photopolymerization of hydrogels - exploiting the self-
assembly properties of phospholipids. Bobone was able to trap an enzyme using nanometeric particles, while still allowing its activity by the diffusion of substrates and products through the network of the polymer. The innovative nanodevices described in this thesis could solve many of the hurdles still hampering the therapeutic application of protein-based drugs.

Keywords

Enzyme Encapsulation Fluorescence Spectroscopy Mechanism of Action of Antimicrobial Peptides Peptide-Membrane Interactions Protein Drug Delivery Selectivity of Antimicrobial Peptides

Authors and affiliations

  • Sara┬áBobone
    • 1
  1. 1.Department of Chemical Sciences and TechnolgiesUniversity of Rome Tor VergataRomeItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-06434-5
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-06433-8
  • Online ISBN 978-3-319-06434-5
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • About this book