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SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

  • Hiroyuki Inuzuka
  • Wenyi Wei

Part of the SpringerBriefs in Cancer Research book series (BRIEFSCANCER)

Table of contents

  1. Front Matter
    Pages i-v
  2. Pengda Liu, Hiroyuki Inuzuka, Wenyi Wei
    Pages 1-13
  3. Alan W. Lau, Yueyong Liu, Adriana E. Tron, Hiroyuki Inuzuka, Wenyi Wei
    Pages 15-45
  4. Brian J. North, Yueyong Liu, Hiroyuki Inuzuka, Wenyi Wei
    Pages 47-71
  5. Jianping Guo, Brian J. North, Adriana E. Tron, Hiroyuki Inuzuka, Wenyi Wei
    Pages 73-87
  6. Jinfang Zhang, Lixin Wan, Brian J. North, Hiroyuki Inuzuka, Wenyi Wei
    Pages 89-111
  7. Pengda Liu, Brian J. North, Hiroyuki Inuzuka, Wenyi Wei
    Pages 113-116
  8. Back Matter
    Pages 117-118

About this book

Introduction

This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.

Keywords

E3 ubiquitin ligase F-box protein oncogene protein degradation ubiquitylation

Authors and affiliations

  • Hiroyuki Inuzuka
    • 1
  • Wenyi Wei
    • 2
  1. 1.Department of PathologyBeth Israel Deaconess Medical Center Harvard Medical SchoolBostonUSA
  2. 2.Department of PathologyBeth Israel Deaconess Medical Center Harvard Medical SchoolBostonUSA

Bibliographic information