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Table of contents

  1. Front Matter
    Pages i-xii
  2. Ali Masoudi-Nejad, Alireza Meshkin
    Pages 53-60
  3. Back Matter
    Pages 61-66

About this book

Introduction

Identifying causal genes underlying susceptibility to human disease is a problem of primary importance in the post-genomic era and in current biomedical research. Recently, there has been a paradigm shift of such gene-discovery efforts from rare, monogenic conditions to common “oligogenic” or “multifactorial” conditions such as asthma, diabetes, cancers and neurological disorders. These conditions are referred to as multifactorial because, susceptibility to these diseases is attributed to the combinatorial effects of genetic variation at a number of different genes and their interaction with relevant environmental exposures. The goal of this book is to introduce gene prioritization aspects and the candidate gene prioritization algorithms to give readers a comprehensive view on the subject.

Keywords

algorithms gene prioritization post-genome

Authors and affiliations

  • Ali Masoudi-Nejad
    • 1
  • Alireza Meshkin
    • 2
  1. 1.Department of BioinformaticsUniversity of Tehran Institute of Biochemistry and BiophysicsTehranIran
  2. 2.University of TehranTehranIran

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-04687-7
  • Copyright Information The Authors 2014
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-04686-0
  • Online ISBN 978-3-319-04687-7
  • Series Print ISSN 2193-4746
  • Series Online ISSN 2193-4754
  • Buy this book on publisher's site