Stereoselective Syntheses of Tetrahydropyrans

Applications to the Synthesis of (+)-Leucascandrolide A, (+)-Dactylolide and (±)-Diospongin A

  • Kiyoun Lee
Part of the Springer Theses book series (Springer Theses)

Table of contents

About this book

Introduction

In his thesis, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and (±)-diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover, the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions, such as those discussed by Lee, has the potential to impact natural product synthesis, pharmaceutical development and chemical biology.
 

Keywords

(+)-Dactylolide (+)-Leucascandrolide A (±)-Diospongin A Gem-disubstituent Effect Tandem Cross-metathesis/thermal SN2′ Tandem and Organocatalytic Oxa-conjugate Addition Tetrahydropyran

Authors and affiliations

  • Kiyoun Lee
    • 1
  1. 1.The Scripps Research InstituteLa JollaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-04462-0
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-04461-3
  • Online ISBN 978-3-319-04462-0
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • About this book