Fluorine in Heterocyclic Chemistry Volume 2

6-Membered Heterocycles

  • Valentine¬†Nenajdenko

Table of contents

  1. Front Matter
    Pages i-x
  2. Anatoliy M. Shestopalov, Lyudmila A. Rodinovskaya, Valeri Yu. Mortikov, Alexander E. Fedorov
    Pages 1-58
  3. Galina N. Lipunova, Emiliya V. Nosova, Valery N. Charushin
    Pages 59-109
  4. Valery N. Charushin, Emiliya V. Nosova, Galina N. Lipunova, Oleg N. Chupakhin
    Pages 111-179
  5. Takeshi Fujita, Junji Ichikawa
    Pages 181-210
  6. Vyacheslav Ya. Sosnovskikh
    Pages 211-290
  7. Dmitriy M. Volochnyuk, Oleksandr O. Grygorenko, Alina O. Gorlova
    Pages 291-575
  8. Dmitriy M. Volochnyuk, Oleksandr O. Grygorenko, Alina O. Gorlova
    Pages 577-672
  9. Vladimir L. Rusinov, Emiliya V. Nosova, Valery N. Charushin
    Pages 673-716
  10. Alan M. Jones, Paul C. M. Winship, John J. Caldwell, Ian Collins
    Pages 717-760
  11. Valentine Nenajdenko
    Pages E1-E1

About this book

Introduction

This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing  6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology.

Keywords

5-membered Rings with Fluorine Substitutions Alkyl-Halides in Heterocyclic Synthesis Drug Design with Fluorine Fluorinated Biomaterials Fluorinated Heterocyclic Chemistry Fluorine in Heterocyclic Chemistry Physiochemical Properties of Fluorinated Heterocyclic Compounds SN2 Reactions with Fluorine Synthetic Fluorochemistry

Editors and affiliations

  • Valentine¬†Nenajdenko
    • 1
  1. 1.Department of ChemistryMoscow State UniversityMoscowRussia

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-04435-4
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-04434-7
  • Online ISBN 978-3-319-04435-4
  • About this book