Fluorine in Heterocyclic Chemistry Volume 1

5-Membered Heterocycles and Macrocycles

  • Valentine Nenajdenko

Table of contents

  1. Front Matter
    Pages i-ix
  2. Nicholas A. Meanwell, Kyle J. Eastman, Eric P. Gillis
    Pages 1-54
  3. Valentine Nenajdenko, Vasiliy M. Muzalevskiy, Olga V. Serdyuk
    Pages 55-115
  4. Vasiliy M. Muzalevskiy, Olga V. Serdyuk, Valentine G. Nenajdenko
    Pages 117-156
  5. Eugene V. Babaev
    Pages 157-180
  6. Alexander V. Butin, Igor V. Trushkov, Olga V. Serdyuk, Vladimir T. Abaev
    Pages 181-231
  7. Olga V. Serdyuk, Vladimir T. Abaev, Alexander V. Butin, Valentine G. Nenajdenko
    Pages 233-277
  8. Santos Fustero, Antonio Simón-Fuentes, Oscar Delgado, Raquel Román
    Pages 279-321
  9. Gordon W. Gribble, Sudipta Roy, Sujata Roy
    Pages 323-367
  10. Andrea Pace, Antonio Palumbo Piccionello, Ivana Pibiri, Silvestre Buscemi, Nicolò Vivona
    Pages 369-417
  11. M. A. Yurovskaya
    Pages 419-458
  12. Vladimir A. Ostrovskii, Rostislav E. Trifonov
    Pages 459-513
  13. Gerd-Volker Röschenthaler, Olesya Kazakova
    Pages 555-587
  14. Stephen G. DiMagno, Justin C. Biffinger, Haoran Sun
    Pages 589-620
  15. Pavel A. Stuzhin
    Pages 621-681
  16. Valentine Nenajdenko
    Pages E1-E1

About this book


This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing  6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology.


5-Membered Rings with Fluorine Substitutions Alkyl-Halides in Heterocyclic Synthesis Drug Design with Fluorine Fluorinated Biomaterials Fluorinated Heterocyclic Chemistry Fluorine in Heterocyclic Chemistry Physiochemical Properties of Fluorinated Heterocyclic Compounds SN2 Reactions with Fluorine Synthetic Fluorochemistry

Editors and affiliations

  • Valentine Nenajdenko
    • 1
  1. 1.Department of ChemistryMoscow State UniversityMoscowRussia

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-04346-3
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-04345-6
  • Online ISBN 978-3-319-04346-3
  • About this book