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Structural and Functional Characterization of the Immunoproteasome

  • Eva Maria Huber
Book

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Eva Maria Huber
    Pages 1-18
  3. Eva Maria Huber
    Pages 19-19
  4. Eva Maria Huber
    Pages 21-39
  5. Eva Maria Huber
    Pages 41-70
  6. Eva Maria Huber
    Pages 71-76
  7. Back Matter
    Pages 77-82

About this book

Introduction

In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.

Keywords

Antigen Generation Drugs for Cancers and Autoimmune Diseases Immunoproteasome X-ray Structure Proteasome Inhibition Protein Crystallography Proteolytic Degradation Structure-based Drug Design Ubiquitin-proteasome System

Authors and affiliations

  • Eva Maria Huber
    • 1
  1. 1.Chair of BiochemistryTechnische Universität MünchenGarchingGermany

Bibliographic information