Calcium Signaling In Airway Smooth Muscle Cells

  • Yong-Xiao Wang

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Kenneth L. Byron, Lioubov I. Brueggemann, Priyanka P. Kakad, Jennifer M. Haick
    Pages 21-33
  3. Jun-Hua Xiao, Yong-Xiao Wang, Yun-Min Zheng
    Pages 35-48
  4. George Gallos, Charles W. Emala Sr.
    Pages 85-106
  5. Qing-Hua Liu, Carlo Savoia, Yong-Xiao Wang, Yun-Min Zheng
    Pages 107-124
  6. Charlotte K. Billington, Ian P. Hall, Carl P. Nelson
    Pages 177-193
  7. Philippe Delmotte, Li Jia, Gary C. Sieck
    Pages 211-234
  8. Christina M. Pabelick, Brij B. Singh, Y. S. Prakash
    Pages 235-246
  9. Deepak A. Deshpande, Alonso Guedes, Mythili Dileepan, Timothy F. Walseth, Mathur S. Kannan
    Pages 247-267
  10. Thai Tran, Chun Ming Teoh
    Pages 309-320
  11. Y. S. Prakash, Venkatachalem Sathish, Elizabeth A. Townsend
    Pages 321-332
  12. Y. S. Prakash, Christina M. Pabelick, Richard J. Martin
    Pages 333-340
  13. James Sneyd, Pengxing Cao, Xiahui Tan, Michael J. Sanderson
    Pages 341-357
  14. Luis M. Montaño, Edgar Flores-Soto, Carlos Barajas-López
    Pages 381-392
  15. Tengyao Song, Yun-Min Zheng, Yong-Xiao Wang
    Pages 393-407
  16. Yunchao Su
    Pages 441-457
  17. Back Matter
    Pages 459-469

About this book


Calcium signaling plays an important role in cellular responses in almost all types of cells including airway smooth muscle cells. This universal signaling may result from extracellular calcium influx and/or intracellular calcium release, which are precisely controlled and regulated by ion channels, exchangers and/or transporters on the plasmalemmal or sarcoplasmic reticulum membrane. First, several chapters detail calcium release channels (ryanodine receptors and inositol trisphosphate receptors), voltage-dependent potassium channels, transient receptor potential channels, Orai channels, calcium-activated potassium channels, and calcium-activated chloride channels. Discussion of well-characterized sodium-calcium exchangers, voltage-dependent calcium channels, and calcium pumps are described in depth over many chapters.   

Ca2+ signaling can be expressed in Ca2+ sparks, waves, oscillations, and global changes in intracellular Ca2+ concentration. Calcium in subcellular compartments (cytosol, sarcoplasmic reticulum, mitochondria, and caveolae) also exhibit dynamic crosstalk. Many molecules including FK506 binding proteins, cyclic adenosine diphosphate ribose, reactive oxygen species, RhoA kinases, caveolin and integrins can modify and induce spatial, temporal and compartmental variations of calcium signaling. In addition, calcium signaling can exhibit sex hormone- and age-dependent changes. A number of chapters are dedicated to covering these diverse formats, spatiotemporal characteristics, multifaceted network and mathematical modeling of Ca2+ signaling.

Neurotransmitters, hormones, growth factors, inflammatory cytokines, and other stimuli may lead to multiple cellular responses by inducing Ca2+ signaling in airway smooth muscle cells. Increasing evidence suggests that Ca2+ pumps and canonical transient receptor potential channels are essential for airway smooth muscle remodeling. Accordingly, several chapters summarize recent advances in the studies of the key role of calcium signaling in physiological cellular responses as well as the development of asthma, chronic obstructive pulmonary disease and other respiratory disorders.


About the Editor

Dr. Yong-Xiao Wang is a Professor at Albany Medical College and has been working on cell calcium, ion channels, and neurotransmitter receptors in airway smooth muscle cells for many years. He has been one of the leading scientists in the field, evident by his excellent record of research publications, funding and service activities.


airway smooth muscle cells asthma calcium signaling calcium sparks

Editors and affiliations

  • Yong-Xiao Wang
    • 1
  1. 1.Albany Medical College Center for Cardiovascular SciencesAlbanyUSA

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