Cerebrospinal Fluid in Clinical Neurology

  • Florian Deisenhammer
  • Finn Sellebjerg
  • Charlotte E Teunissen
  • Hayrettin Tumani

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Basic Aspects of the Cerebrospinal Fluid

    1. Front Matter
      Pages 1-1
    2. Florian Deisenhammer
      Pages 3-16
    3. Hayrettin Tumani
      Pages 25-34
    4. Ellis Niemantsverdriet, Hanne Struyfs, Flora Duits, Charlotte E. Teunissen, Sebastiaan Engelborghs
      Pages 35-57
    5. Eline A. J. Willemse, Charlotte E. Teunissen
      Pages 59-77
  3. Methods of CSF Analyses

    1. Front Matter
      Pages 79-79
    2. Herwig Strik, Ingelore Nagel
      Pages 81-100
    3. Hayrettin Tumani, Harald Hegen
      Pages 101-106
    4. Hayrettin Tumani, Harald Hegen
      Pages 107-109
    5. Finn Sellebjerg
      Pages 115-129
    6. Annette Spreer
      Pages 131-142
    7. Romana Höftberger, Simone Mader, Markus Reindl
      Pages 143-158
    8. Diego Franciotta, Massimo Alessio, Livia Garzetti, Roberto Furlan
      Pages 159-171
  4. CSF in Clinical Syndromes

    1. Front Matter
      Pages 173-173
    2. Erich Schmutzhard, Bettina Pfausler
      Pages 175-209
    3. Agnes van Sonderen, Maarten J. Titulaer
      Pages 247-276
    4. Irina Elovaara, Sanna Hagman, Aki Hietaharju
      Pages 277-291
    5. Christoffer Rosén, Henrik Zetterberg, Kaj Blennow
      Pages 329-351
    6. Jan Lewerenz, Frank Leypoldt
      Pages 353-385
    7. Markus Otto, Karin Nagy, Niklas Mattson
      Pages 387-394
    8. Geoffrey Keir, Ligy Thomas
      Pages 395-406
    9. Harald Hegen, Charlotte E. Teunissen, Finn Sellebjerg, Hayrettin Tumani, Florian Deisenhammer
      Pages 407-428
  5. Back Matter
    Pages 429-441

About this book


The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be conducted using relatively simple laboratory methods. By combining different CSF parameters, a wide range of diagnostic entities can be identified. However, properly interpreting the test results requires a high level of expertise and cannot be achieved by just reporting on individual analytic values. This book covers essential aspects of cerebrospinal fluid analysis and its use in the diagnosis of common neurological diseases. The first part addresses preclinical aspects such as the history of CSF, as well as the anatomical, physiological, and biological background of this valuable fluid. In addition, CSF collection, its preanalytical and methodological implications, and the increasing number of disease-specific markers in CSF are discussed in detail. Lastly, CSF analyses are put into context with clinical syndromes, demonstrating their diagnostic value in neurological clinical practice. Cerebrospinal Fluid in Clinical Neurology helps readers understand the preanalytical and analytical aspects of CSF diagnostics and offers a valuable reference guide for interpreting CSF results during the clinical work-up for neurological patients.  


CSF biomarkers laboratory medicine liquor diagnostics lumbar puncture neurological diseases

Editors and affiliations

  • Florian Deisenhammer
    • 1
  • Finn Sellebjerg
    • 2
  • Charlotte E Teunissen
    • 3
  • Hayrettin Tumani
    • 4
  1. 1.Department of NeurologyInnsbruck Medical UniversityInnsbruckAustria
  2. 2.Department of NeurologyDanish Multiple Sclerosis Center Rigshospitalet, University of CopenhagenCopenhagenDenmark
  3. 3.Department of Clinical ChemistryVU University Medical Center Amsterdam Neurochemistry Laboratory and BiobankAmsterdamThe Netherlands
  4. 4.Department of NeurologyUniversity of UlmUlmGermany

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-01224-7
  • Online ISBN 978-3-319-01225-4
  • Buy this book on publisher's site