Percutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products

Development of Analytical Methods

  • Zacarías León González

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Zacarías León González
      Pages 3-23
  3. In Vitro Methodology

  4. In Vivo Methodology

  5. Summary and General Conclusions

    1. Front Matter
      Pages 195-195
    2. Zacarías León González
      Pages 201-205
  6. Back Matter
    Pages 207-216

About this book


Zacarías León's thesis describes the development and validation of analytical methods to estimate the processes set in motion by percutaneous absorption of UV filters in sunscreen cosmetic products. León describes these methods in both in vitro and non-invasive in vivo methodologies. Currently dermatologists recommend the use of sunscreen products not only under conditions of extreme exposure to the sun but also in daily situations. However the chemical compounds in these products contain may lead to undesired processes and cause induced toxicity, estogenic effects and endocrine activity. León establishes methods to investigate these effects and provides valuable information on the undesired side effects associated with the use of UV filters found in sunscreen products. The work in this thesis has led to a number of publications in renowned analytical chemistry journals.


Bioanalytical Methods Biological Fluids (urine and semen) Cosmetics Gas Chromatography-Mass Spectrometry In Vivo and in Vitro Metabolism Liquid Chromatography-Mass Spectrometry Percutaneous Absorption Solid-Phase Extraction UV Filters

Authors and affiliations

  • Zacarías León González
    • 1
  1. 1.Department of Analytical ChemistryUniversity of Valencia, Faculty of ChemistryValenciaSpain

Bibliographic information