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Organotrifluoroborate Preparation, Coupling and Hydrolysis

  • Alastair J. J.┬áLennox

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Alastair J. J. Lennox
    Pages 1-9
  3. Alastair J. J. Lennox
    Pages 11-36
  4. Alastair J. J. Lennox
    Pages 37-80
  5. Alastair J. J. Lennox
    Pages 81-131
  6. Alastair J. J. Lennox
    Pages 133-146
  7. Alastair J. J. Lennox
    Pages 147-223

About this book

Introduction

Alistair Lennox's thesis reports on the reactivity of organotrifluoroborates, which are becoming increasingly important reagents in synthesis. The thesis is divided into three sections. The first section describes a method for preparing organotrifluoroborates. The second section reports on a mechanistic investigation into the main application of RBF3K reagents as coupling partners in Suzuki-Miyaura coupling, phenomena identified as arising from organotrifluoroborate hydrolysis and fluoride release. The final section reports on a detailed investigation into the hydrolysis mechanism, a prerequisite for their Suzuki-Miyaura coupling, and how it may be predicted and controlled. This research has uncovered many interesting and useful details and shows how problems associated with Suzuki-Miyaura coupling can best be addressed. There has already been wide industrial uptake of the new procedures and insights. The broad nature and clear and succinct style will make the thesis a valuable resource for anyone working in synthesis, organometallic chemistry, or in homogeneous catalysis.

Keywords

Cross-coupling Glassware Etching Kinetics of Hydrolysis Organotrifluoroborate Salts Side-product Suppression Suzuki-Miyaura Coupling Mechanism Trifluoroborate Reactivity Trifluoroborates

Authors and affiliations

  • Alastair J. J.┬áLennox
    • 1
  1. 1.School of ChemistryUniversity of BristolBristolUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-01134-9
  • Copyright Information Springer International Publishing Switzerland 2013
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-01133-2
  • Online ISBN 978-3-319-01134-9
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • Buy this book on publisher's site