Towards Dual and Targeted Cancer Therapy with Novel Phthalocyanine-based Photosensitizers

  • Janet T F Lau
Part of the Springer Theses book series (Springer Theses)

About this book

Introduction

Janet Lau's thesis describes her studies into the use of phthalocyanine-based photosensitizers in combined chemo- and photodynamic therapy (PDT) and targeted PDT. In order to carry out this study, Lau uses several approaches: conjugation with a chemotherapeutic oxaliplatin derivative, use of a polyamine ligand 2 with a view to targeting the polyamine transporters over-expressed in tumor cells, and employment of a quencher that can inhibit their photodynamic activity but can still be removed under a tumor-associated environment such as low pH and high thiol concentration. This thesis reports dual activatable photosensitizers for the first time. Overall the studies included are original and the effects have been well demonstrated at the cellular level. The work in this thesis is of much current interest and importance, and can pave foundation for further developments. Accordingly, parts of the results have been published in prestigious scientific journals.

Keywords

Activatable Photosensitizer Dual Therapy Oxaliplatin Derivative Photodynamic Therapy Phthalocyanine Phthalocyanine-Polyamine Conjugates Platinum Redox-Responsive Silicon Phthalocyanine Targeted Photodynamic Therapy

Authors and affiliations

  • Janet T F Lau
    • 1
  1. 1., Department of ChemistryThe Chinese University of Hong KongShatinChina, People's Republic

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-00708-3
  • Copyright Information Springer International Publishing Switzerland 2013
  • Publisher Name Springer, Heidelberg
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-00707-6
  • Online ISBN 978-3-319-00708-3
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061