New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids

  • Ana¬†Escribano Cuesta

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Ana Escribano Cuesta
    Pages 1-35
  3. Escribano Cuesta Ana
    Pages 105-189
  4. Ana Escribano Cuesta
    Pages 191-195

About this book


Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.


Antonio M. Echavarren Cyclization of Alkynylindole Cyclobutene Compounds Gold Properties Gold(I)-Catalyzed Cycloisomerization Gold-Catalyzed Nucleophilic Additions Indoloazocine Framework Lundurines A-D Metal-Catalyzed Alkyne Activation Total Synthesis of Lundurines

Authors and affiliations

  • Ana¬†Escribano Cuesta
    • 1
  1. 1.Lead Optimization FungicidesBASF SE.LudwigshafenGermany

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2013
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-00701-4
  • Online ISBN 978-3-319-00702-1
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
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