Iron Acquisition by the Genus Mycobacterium

History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development

  • B. Rowe Byers

Part of the SpringerBriefs in Molecular Science book series (BRIEFSMOLECULAR)

Also part of the SpringerBriefs in Biometals book sub series (SB BIOMETALS)

Table of contents

  1. Front Matter
    Pages i-v
  2. B. Rowe Byers
    Pages 1-2
  3. B. Rowe Byers
    Pages 41-52
  4. Benjamin E. Allred, Allyson K. Sia, Kenneth N. Raymond
    Pages 53-64
  5. Back Matter
    Pages 89-92

About this book

Introduction

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

Keywords

Antibiotic Development Haem Iron Heme Iron Iron Sources Organisms M. Tuberculosis Mycobacterial Disease Siderocalin Enterobactin Siderophores Iron Transporter

Editors and affiliations

  • B. Rowe Byers
    • 1
  1. 1., MicrobiologyUniversity of Mississippi Medical CenterMadisonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-00303-0
  • Copyright Information The Author(s) 2013
  • Publisher Name Springer, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-00302-3
  • Online ISBN 978-3-319-00303-0
  • Series Print ISSN 2191-5407
  • Series Online ISSN 2191-5415
  • About this book