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Central Cholinergic Synaptic Transmission

  • Michael Frotscher
  • Ulrich Misgeld

Part of the Experientia Supplementum book series (EXS, volume 57)

Table of contents

  1. Front Matter
    Pages I-X
  2. Cholinergic neurons, pathways and synapses

  3. Acetylcholine-induced postsynaptic potentials and excitatory changes

  4. Cholinergic receptor types and their modulation

    1. Heinrich Betz, Eckart D. Gundelfinger, Irm Hermans-Borgmeyer, Erich Sawruk, Patrick Schloß, Bertram Schmitt
      Pages 183-189
    2. Takashi Akasu, Takayuki Tokimasa
      Pages 190-196
    3. K. Zilles, H. Schröder, U. Schröder, E. Horvath, L. Werner, P. G. M. Luiten et al.
      Pages 212-228
  5. Acetylcholine and Plasticity of the CNS

    1. Donald J. Jenden, Roger W. Russell, Ruth A. Booth, Beat J. Knusel, Sharlene D. Lauretz, Kathleen M. Rice et al.
      Pages 229-235
    2. Beat H. Gähwiler, David A. Brown, Albert Enz, Thomas Knöpfel
      Pages 236-250
    3. C. Grothe, D. Otto, M. Frotscher, K. Uniscker
      Pages 251-258
    4. Fred H. Gage, Mark H. Tuszynski, Karen S. Chen, David Armstrong, György Buzsàki
      Pages 259-274
    5. P. Calabresi, A. Stefani, N. B. Mercuri, G. Bernardi
      Pages 315-321
  6. Back Matter
    Pages 322-323

About this book

Introduction

Our knowledge of cholinergic synaptic transmission in the peripheral nervous system (PNS) has expanded enormously since the early 1930's, at which time O. Loewi discovered chemical neurotransmission through acetylcholine (ACh) and the pharmacological actions of ACh were described by H. Dale and his colleagues. Description of ACh's actions and receptors in various parts of the brain was followed by a detailed analysis of ACh's synthesis, release mechanism, removal from the synaptic cleft, modes of agonist-receptor interactions, properties of regulated conductances and of the pre-and postsynaptic modulation of cholinergic synapses. Our knowledge has been increasingly consolidat­ ing, leading us to the recent clarification of the structure of the periph­ eral nicotinic receptor-ion channel and its functional properties. It is appropriate to maintain the claim that the fundamentals of our under­ standing of synaptic transmission come from studies on cholinergic synapses in the PNS. Contrastingly, views held on the role of cholinergic synapses in the mammalian central nervous system (CNS) are extremely controversial, although it has been clear for some time that ACh is present in the brain. Illustrating this, no unanimous view is held on the role of nicotinic receptors in the CNS. There is one notable exception to this confusion: Studies begun by J. C. Eccles and associates in the 1960's and completed by D. R. Curtis and R. W.

Keywords

Nervous System Parkinson anatomy cortex forebrain neurons

Editors and affiliations

  • Michael Frotscher
    • 1
  • Ulrich Misgeld
    • 2
  1. 1.Anatomisches InstitutJ.W. Goethe-UniversitätFrankurt a.M 70Federal Republic of Germany
  2. 2.Max-Planck-Institut für PsychiatriePlanegg-MartinsriedFederal Republic of Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-0348-9138-7
  • Copyright Information Birkhäuser Basel 1989
  • Publisher Name Birkhäuser Basel
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-0348-9922-2
  • Online ISBN 978-3-0348-9138-7
  • Series Print ISSN 1023-294X
  • Buy this book on publisher's site